ArticleActa biomaterialia2012
Intra-articular controlled release of anti-inflammatory siRNA with biodegradable polymer microparticles ameliorates temporomandibular joint inflammation.
Article in Acta biomaterialia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- PLGA Nanoparticle-Mediated Sustained Release of Fisetin for Intra-Articular Therapy of Temporomandibular Joint Osteoarthritis.International journal of molecular sciences · 2026Article
- Scaffolds and Stem Cells Show Promise for TMJ Regeneration: A Systematic Review.Bioengineering (Basel, Switzerland) · 2026Review
- Drug delivery systems for treatment of temporomandibular joint osteoarthritis.Frontiers in pharmacology · 2022Review
- Article
- Toward a Better Regeneration through Implant-Mediated Immunomodulation: Harnessing the Immune Responses.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective.Frontiers in pharmacology · 2020Review
- Biomaterials: Foreign Bodies or Tuners for the Immune Response?International journal of molecular sciences · 2019Review
- Macrophages Are Key Regulators of Stem Cells during Skeletal Muscle Regeneration and Diseases.Stem cells international · 2019Review
- Engineered Hydrogels for Local and Sustained Delivery of RNA-Interference Therapies.Advanced healthcare materials · 2017Review
- Photocleavable Hydrogels for Light-Triggered siRNA Release.Advanced healthcare materials · 2016Article
- Technologies for controlled, local delivery of siRNA.Journal of controlled release : official journal of the Controlled Release Society · 2015Review
- siRNA Versus miRNA as Therapeutics for Gene Silencing.Molecular therapy. Nucleic acids · 2015Review
- Biomaterial-mediated modification of the local inflammatory environment.Frontiers in bioengineering and biotechnology · 2015Review
- Tunable delivery of siRNA from a biodegradable scaffold to promote angiogenesis in vivo.Advanced materials (Deerfield Beach, Fla.) · 2014Article
- Modulation of polyplex release from biodegradable microparticles through poly(ethylenimine) modification and varying loading concentration.Pharmaceutical research · 2014Article
- Intra-articular biomaterials-assisted delivery to treat temporomandibular joint disorders.Journal of tissue engineeringArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
We investigated the in vivo therapeutic efficacy of an intra-articular controlled release system consisting of biodegradable poly(dl-lactic-co-glycolic acid) (PLGA) microparticles (MPs) encapsulating anti-inflammatory small interfering RNA (siRNA), together with branched poly(ethylenimine) (PEI) as a transfecting agent, in a rat model of painful temporomandibular joint (TMJ) inflammation. The in vivo effects of PLGA MP dose and siRNA-PEI polyplex delivery were examined via non-invasive meal pattern analysis and by quantifying the protein level of the siRNA target as well as of several downstream inflammatory cytokines. Controlled release of siRNA-PEI from PLGA MPs significantly reduced inflammation-induced changes in meal patterns compared to untreated rats with inflamed TMJs. These changes correlated to decreases in tissue-level protein expression of the siRNA target to 20-50% of the amount present in the corresponding control groups. Similar reductions were also observed in the expression of downstream inflammatory cytokines, e.g. interleukin-6, whose tissue levels in the siRNA-PEI PLGA MP groups were 50% of the values for the corresponding controls. This intra-articular sustained release system has significant implications for the treatment of severe TMJ pain, and also has the potential to be readily adapted and applied to mitigate painful, chronic inflammation in a variety of conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.