ArticlePharmacology, biochemistry, and behavior2012
Post-conditioning propranolol disrupts cocaine sensitization.
Article in Pharmacology, biochemistry, and behavior, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 10 citations in OpenAlex.
- Chronic administration of a norepinephrine antagonist prevents and partially reverses escalation of cocaine self-administration.Addiction biology · 2023Article
- Memory Impairing Effect of Propranolol on Consolidation and Reconsolidation for Various Learning Tasks.Noro psikiyatri arsivi · 2023Review
- Adrenaline rush: the role of adrenergic receptors in stimulant-induced behaviors.Molecular pharmacology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Antagonists of β-adrenergic receptors (β-ARs) have previously been demonstrated to impair long-term memory in a variety of animal behavioral paradigms. Surprisingly little is known about the ability of β-ARs to modulate initial memory formation in drug conditioning paradigms. The current study examined whether the post-training administration of the β-AR antagonist, propranolol, would disrupt single-trial cocaine-induced sensitization. Rats received 10 mg/kg propranolol immediately following a 30-min cocaine or vehicle exposure in a conditioning context and were later tested for their locomotor response to a cocaine challenge. Rats that received propranolol following cocaine conditioning showed an impairment of locomotor sensitization during testing. However, this effect was only seen in animals with an initial sensitivity to the locomotor effects of cocaine. Rats that failed to show a locomotor response to cocaine during conditioning were not affected by propranolol. We discuss the implications of these findings as they relate to drug conditioning and memory consolidation studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.