ArticleEuropean journal of medicinal chemistry2012
Synthesis and evaluation of carbocyanine dyes as PRMT inhibitors and imaging agents.
Article in European journal of medicinal chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 50 citations in OpenAlex.
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- Biomimetic NIR-II fluorescent proteins created from chemogenic protein-seeking dyes for multicolor deep-tissue bioimaging.Nature communications · 2024Article
- Site-specific albumin tagging with NIR-II fluorogenic dye for high-performance and super-stable bioimaging.Theranostics · 2024Article
- Chemical probes and methods for the study of protein arginine methylation.RSC chemical biology · 2023Review
- Improved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic cancer.Scientific reports · 2021Article
- Current trends in pyrrole and porphyrin-derived nanoscale materials for biomedical applications.Nanomedicine (London, England) · 2020Review
- PRMT6 Promotes Lung Tumor Progression via the Alternate Activation of Tumor-Associated Macrophages.Molecular cancer research : MCR · 2020Article
- Second Generation G-Quadruplex Stabilizing Trimethine Cyanines.Bioconjugate chemistry · 2019Article
- Mechanisms and Inhibitors of Histone Arginine Methylation.Chemical record (New York, N.Y.) · 2018Review
- Inhibitors of Protein Methyltransferases and Demethylases.Chemical reviews · 2018Review
- Listening to membrane potential: photoacoustic voltage-sensitive dye recording.Journal of biomedical optics · 2017Article
- Transient Kinetics Define a Complete Kinetic Model for Protein Arginine Methyltransferase 1.The Journal of biological chemistry · 2016Article
- Protein Arginine Methylation and Citrullination in Epigenetic Regulation.ACS chemical biology · 2016Article
- Small Molecule Inhibitors of Protein Arginine Methyltransferases.Expert opinion on investigational drugs · 2016Review
- Benz[c,d]indolium-containing Monomethine Cyanine Dyes: Synthesis and Photophysical Properties.Molecules (Basel, Switzerland) · 2015Article
- Exploration of cyanine compounds as selective inhibitors of protein arginine methyltransferases: synthesis and biological evaluation.Journal of medicinal chemistry · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Protein arginine methylation regulates multiple biological processes. Deregulation of protein arginine methyltransferase (PRMT) activities has been observed in many disease phenotypes. Small molecule probes that target PRMTs with strong affinity and selectivity can be used as valuable tools to dissect biological mechanisms of arginine methylation and establish the role of PRMT proteins in a disease process. In this work, we report synthesis and evaluation of a class of carbocyanine compounds containing indolium, benz[e]indolium or benz[c,d]indolium heterocyclic moieties that bind to the predominant arginine methyltransferase PRMT1 and inhibit its methyltransferase activity at low micromolar potencies. In particular, the developed molecules have long wavelength colorimetric and fluorometric photoactivities, which can be used for optical and near-infrared fluorescence imaging in cells or biological tissues. Together, these new chemical probes have potential application in PRMT studies both as enzyme inhibitors and as fluorescent dyes for microscope imaging.
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Registered trials
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