ArticleMolecular cell2012
A bridging model for persistence of a polycomb group protein complex through DNA replication in vitro.
Article in Molecular cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 49 citations in OpenAlex.
- Graded versus ON/OFF control in quantitative gene expression and epigenetic memory.The EMBO journal · 2026Review
- Replication-coupled inheritance of chromatin states.Cell insight · 2024Review
- A Two-Step Mechanism for Creating Stable, Condensed Chromatin with the Polycomb Complex PRC1.Molecules (Basel, Switzerland) · 2024Article
- Regulation of the heterochromatin spreading reaction byOpen biology · 2023Review
- Roles of Polycomb complexes in regulating gene expression and chromatin structure in plants.Plant communications · 2022Review
- The Paramount Role ofInsects · 2021Review
- Hybrid protein assembly-histone modification mechanism for PRC2-based epigenetic switching and memory.eLife · 2021Article
- The Trithorax group protein ASH1 requires a combination of BAH domain and AT hooks, but not the SET domain, for mitotic chromatin binding and survival.Chromosoma · 2021Article
- Differential Histone Distribution Patterns in Induced Asymmetrically Dividing Mouse Embryonic Stem Cells.Cell reports · 2020Article
- DNA Binding Reorganizes the Intrinsically Disordered C-Terminal Region of PSC in Drosophila PRC1.Journal of molecular biology · 2020Article
- Arabidopsis DNA polymerase ϵ recruits components of Polycomb repressor complex to mediate epigenetic gene silencing.Nucleic acids research · 2016Article
- Maintaining Epigenetic Inheritance During DNA Replication in Plants.Frontiers in plant science · 2016Review
- Replicating Nucleosomes.Science advances · 2015Article
- Review
- How the cell cycle impacts chromatin architecture and influences cell fate.Frontiers in genetics · 2015Article
- Epigenetic inheritance: histone bookmarks across generations.Trends in cell biology · 2014Review
- Modeling epigenome folding: formation and dynamics of topologically associated chromatin domains.Nucleic acids research · 2014Article
- Role of chromatin in water stress responses in plants.Journal of experimental botany · 2014Review
- What are memories made of? How Polycomb and Trithorax proteins mediate epigenetic memory.Nature reviews. Molecular cell biology · 2014Review
- Maintenance of epigenetic information: a noncoding RNA perspective.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2013Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Epigenetic regulation may involve heritable chromatin states, but how chromatin features can be inherited through DNA replication is incompletely understood. We address this question using cell-free replication of chromatin. Previously, we showed that a Polycomb group complex, PRC1, remains continuously associated with chromatin through DNA replication. Here we investigate the mechanism of persistence. We find that a single PRC1 subunit, Posterior sex combs (PSC), can reconstitute persistence through DNA replication. PSC binds nucleosomes and self-interacts, bridging nucleosomes into a stable, oligomeric structure. Within these structures, individual PSC-chromatin contacts are dynamic. Stable association of PSC with chromatin, including through DNA replication, depends on PSC-PSC interactions. Our data suggest that labile individual PSC-chromatin contacts allow passage of the DNA replication machinery while PSC-PSC interactions prevent PSC from dissociating, allowing it to rebind to replicated chromatin. This mechanism may allow inheritance of chromatin proteins including PRC1 through DNA replication to maintain chromatin states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.