ArticleCancer genetics2012
EWS/FLI-responsive GGAA microsatellites exhibit polymorphic differences between European and African populations.
Article in Cancer genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- Genome-wide association study meta-analysis identifies susceptibility loci informing Ewing sarcoma etiology and potential mechanisms of risk.medRxiv : the preprint server for health sciences · 2026Article
- Epidemiology, incidence, and outcome of childhood cancers in the Afro-descendant population of the French West Indies and French Guiana: a population-based study.Lancet regional health. Americas · 2025Article
- Primary and Metastatic Pancreatic Ewing Sarcomas: A Case Report and Review of the Literature.Diagnostics (Basel, Switzerland) · 2024Review
- Ewing Sarcoma in the Pediatric Population: Predictors of Survival Within the United States.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2024Article
- Disparities in incidence and survival for patients with Ewing sarcoma in Florida.Cancer medicine · 2024Article
- EWS/FLI1 Characterization, Activation, Repression, Target Genes and Therapeutic Opportunities in Ewing Sarcoma.International journal of molecular sciences · 2023Review
- Systematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulation.Cell reports · 2022Article
- Comparative international incidence of Ewing sarcoma 1988 to 2012.International journal of cancer · 2021Article
- Genome-wide characterization of human minisatellite VNTRs: population-specific alleles and gene expression differences.Nucleic acids research · 2021Article
- Racial and Ethnic Differences in Sarcoma Incidence Are Independent of Census-Tract Socioeconomic Status.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- Review
- Extraosseus Ewing's Sarcoma in Pancreas: A Review.Cureus · 2020Review
- Are EWSR1-NFATc2-positive sarcomas really Ewing sarcomas?Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018Article
- Intracardiac Low-grade Sarcoma Following Treatment for Ewing Sarcoma.Journal of pediatric hematology/oncology · 2017Article
- Role for the EWS domain of EWS/FLI in binding GGAA-microsatellites required for Ewing sarcoma anchorage independent growth.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Combined experience of six independent laboratories attempting to create an Ewing sarcoma mouse model.Oncotarget · 2017Article
- Cancer of childhood in sub-Saharan Africa.Ecancermedicalscience · 2017Review
- Widespread Chromatin Accessibility at Repetitive Elements Links Stem Cells with Human Cancer.Cell reports · 2016Article
- Linking germline and somatic variation in Ewing sarcoma.Nature genetics · 2015Article
- Sequencing Overview of Ewing Sarcoma: A Journey across Genomic, Epigenomic and Transcriptomic Landscapes.International journal of molecular sciences · 2015Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
The genetics of Ewing sarcoma development remain obscure. The incidence of Ewing sarcoma is ten-fold less in Africans as compared to Europeans, irrespective of geographic location, suggesting population-specific genetic influences. Since GGAA-containing microsatellites within key target genes are necessary for Ewing sarcoma-specific EWS/FLI DNA binding and gene activation, and gene expression is positively correlated with the number of repeat motifs in the promoter/enhancer region, we sought to determine if significant polymorphisms exist between African and European populations which might contribute to observed differences in Ewing sarcoma incidence and outcomes. GGAA microsatellites upstream of two critical EWS/FLI target genes, NR0B1 and CAV1, were sequenced from subjects of European and African descent. While the characteristics of the CAV1 promoter microsatellites were similar across both populations, the NR0B1 microsatellite in African subjects was significantly larger, harboring more repeat motifs, a greater number of repeat segments, and longer consecutive repeats, than in European subjects. These results are biologically intriguing as NR0B1 was the most highly enriched EWS/FLI bound gene in prior studies, and is absolutely necessary for oncogenic transformation in Ewing sarcoma. These data suggest that GGAA microsatellite polymorphisms in the NR0B1 gene might influence disease susceptibility and prognosis in Ewing sarcoma in unanticipated ways.
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Registered trials
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