ArticleMetabolism: clinical and experimental2012
Insulin sensitivity is associated with thigh adipose tissue distribution in healthy postmenopausal women.
Article in Metabolism: clinical and experimental, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 44 citations in OpenAlex.
- Effect of Aerobic or Resistance Exercise, or Both, on Intermuscular and Visceral Fat and Physical and Metabolic Function in Older Adults With Obesity While Dieting.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Trial
- Sex-specific protective role of lower-body fat in type 2 diabetes: mediation through insulin resistance in a BMI-matched population.BMJ open diabetes research & care · 2025Article
- Mechanisms of body fat distribution and gluteal-femoral fat protection against metabolic disorders.Frontiers in nutrition · 2024Review
- Thigh muscle fat fraction is independently associated with impaired glucose metabolism in individuals with obesity.Endocrine connections · 2023Article
- Aerobic exercise and metformin on intermuscular adipose tissue (IMAT): insights from multimodal MRI and histological changes in prediabetic rats.Diabetology & metabolic syndrome · 2023Article
- The Important Role of Intermuscular Adipose Tissue on Metabolic Changes Interconnecting Obesity, Ageing and Exercise: A Systematic Review.TouchREVIEWS in endocrinology · 2023Review
- Associations of renal sinus fat with blood pressure and ectopic fat in a diverse cohort of adults.International journal of cardiology. Cardiovascular risk and prevention · 2023Article
- Associations of atrial natriuretic peptide with measures of insulin and adipose depots.Physiological reports · 2023Article
- Obesity risk is associated with brain glucose uptake and insulin resistance.European journal of endocrinology · 2022Article
- From an Apple to a Pear: Moving Fat around for Reversing Insulin Resistance.International journal of environmental research and public health · 2022Review
- Muscle fat infiltration but not muscle cross-sectional area is independently associated with bone mineral density at the lumbar spine.The British journal of radiology · 2022Article
- Sex differences in the relationships between body composition, fat distribution, and mitochondrial energy metabolism: a pilot study.Nutrition & metabolism · 2022Article
- Relative associations of abdominal and thigh compositions with cardiometabolic diseases in African Caribbean men.Obesity science & practice · 2021Article
- Relationships between plasma apelin and adiponectin with normal weight obesity, body composition, and cardiorespiratory fitness in working adults.Journal of clinical & translational endocrinology · 2021Article
- Article
- Intermuscular Fat Content in Young Chinese Men With Newly Diagnosed Type 2 Diabetes: Based on MR mDIXON-Quant Quantitative Technique.Frontiers in endocrinology · 2021Article
- Increased Skeletal Muscle Fiber Cross-Sectional Area, Muscle Phenotype Shift, and Altered Insulin Signaling in Rat Hindlimb Muscles in a Prenatally Androgenized Rat Model for Polycystic Ovary Syndrome.International journal of molecular sciences · 2020Article
- Race affects the association of obesity measures with insulin sensitivity.The American journal of clinical nutrition · 2020Article
- Role of Metabolic Stress and Exercise in Regulating Fibro/Adipogenic Progenitors.Frontiers in cell and developmental biology · 2020Review
- Effects of weight loss during a very low carbohydrate diet on specific adipose tissue depots and insulin sensitivity in older adults with obesity: a randomized clinical trial.Nutrition & metabolism · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
objectiveEvidence suggests intermuscular adipose tissue (IMAT) may be linked to insulin resistance, whereas thigh subcutaneous adipose tissue (SAT) may be related favorably with indices of metabolic health. However, whether adipose tissue depots of the thigh are differentially related to insulin sensitivity independent of total adiposity and other adipose tissue depots has not been determined. The objective of this study was to identify independent associations of the subcompartments of adipose tissue of the thigh with insulin sensitivity among 97 healthy early postmenopausal women. MATERIALS AND
methodsComputed tomography (CT) scans of the mid-thigh were used to assess Thigh-SAT, Thigh perimuscular adipose tissue (PMAT), and Thigh-IMAT. CT scans at the L4-L5 intervertebral space were used to assess intra-abdominal adipose tissue (IAAT) and Abdominal-SAT. Total body fat was measured by dual-energy X-ray absorptiometry (DXA). The insulin sensitivity index (S(I)) was assessed by using a frequently sampled intravenous glucose tolerance test with minimal model analysis.
resultsResults indicated S(I) was positively associated with Thigh-SAT independent of total fat mass and other adipose tissue compartments. Among all women combined, S(I) was inversely associated with Thigh-IMAT independent of total fat mass. However, the relationship between S(I) and Thigh-IMAT was independent of IAAT only among women with high levels of Thigh-IMAT and IAAT.
conclusionsThis is the first study to demonstrate independent, opposing relationships of Thigh-SAT and Thigh-IMAT with insulin sensitivity in healthy postmenopausal women. Further research is needed to determine if these associations are causal in nature.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.