Evidence map›Paper›PMID 22748592›Full record

ReviewLancet (London, England)2012

Cholera.

Jason B Harris, Regina C LaRocque, Firdausi Qadri, Edward T Ryan, Stephen B Calderwood

Open access · bronzeAbstract readReview
In one paragraph

Review in Lancet (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 332 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
332citing papers in PubMed, 4 pooled it
28.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

332 citing papers in PubMed, 4 syntheses or guidelines pooled it, 586 citations in OpenAlex.

  1. Pooled it
  2. Cholera in travellers: a systematic review.Journal of travel medicine · 2019
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Article
  8. Article
  9. Molecular characterization ofIJID regions · 2026
    Article
  10. Article
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  19. Chromosome-borneIranian journal of microbiology · 2026
    Article
  20. Public health surveillance ofJournal of medical microbiology · 2026
    Article

272 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Jason B HarrisDivision of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Regina C LaRocqueDivision of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA.
Firdausi QadriInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Edward T RyanDivision of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA.
Stephen B CalderwoodDivision of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA. Electronic address: scalderwood@partners.org.
International Centre for Diarrhoeal Disease Research · BDMassachusetts General Hospital · US

Funding

Protecutive immunity to human cholera in BangladeshU01AI058935 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI CALDERWOOD, STEPHEN B., RYAN, EDWARD T. · 2003 to 2014
$7.8M
High throughput NAPPA-proteoimmunomics and Vibrio cholerae vaccine developmentU01AI077883 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RYAN, EDWARD T. · 2008 to 2012
$5.6M
The role of TcpA in cholera immunity and vaccinationK01TW007409 · FIC · MASSACHUSETTS GENERAL HOSPITAL · PI HARRIS, JASON B · 2005 to 2011
$867k
FIC NIH HHS K01 TW007409FIC NIH HHS K01 TW07409Howard Hughes Medical InstituteNIAID NIH HHS AI058935NIAID NIH HHS U01 AI058935NIAID NIH HHS U01 AI077883
6 · The paper itself

Abstract

Cholera is an acute, secretory diarrhoea caused by infection with Vibrio cholerae of the O1 or O139 serogroup. It is endemic in more than 50 countries and also causes large epidemics. Since 1817, seven cholera pandemics have spread from Asia to much of the world. The seventh pandemic began in 1961 and affects 3-5 million people each year, killing 120,000. Although mild cholera can be indistinguishable from other diarrhoeal illnesses, the presentation of severe cholera is distinct, with pronounced diarrhoeal purging. Management of patients with cholera involves aggressive fluid replacement; effective therapy can decrease mortality from more than 50% to less than 0·2%. Antibiotic treatment decreases volume and duration of diarrhoea by 50% and is recommended for patients with moderate to severe dehydration. Prevention of cholera depends on access to safe water and sanitation. Two oral cholera vaccines are available and the most effective use of these in integrated prevention programmes is being actively assessed.

Indexed as

Anti-Bacterial AgentsCholeraCholera VaccinesFluid TherapyHumansAnti-Bacterial AgentsCholera Vaccines

Identifiers

PMID22748592
PMCPMC3761070
OpenAlexW4211113784

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.