ReviewSleep medicine reviews2013
The comorbidity of insomnia, chronic pain, and depression: dopamine as a putative mechanism.
Review in Sleep medicine reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 154 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
154 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Effects of pharmacological and non-pharmacological interventions for the management of sleep problems in people with fibromyalgia: a multi-methods evidence synthesis.Health technology assessment (Winchester, England) · 2025Pooled it
- Dysregulated anterior insula reactivity as robust functional biomarker for chronic pain-Meta-analytic evidence from neuroimaging studies.Human brain mapping · 2022Pooled it
- Sleep disturbances and back pain : Systematic review and meta-analysis.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2020Pooled it
- Sleep and Pain: A Systematic Review of Studies of Mediation.The Clinical journal of pain · 2019Pooled it
- Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews.The Cochrane database of systematic reviews · 2017Pooled it
- Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews.The Cochrane database of systematic reviews · 2017Pooled it
- Pooled it
- A non-inferiority randomized controlled trial comparing behavioral sleep interventions in women veterans: An examination of pain outcomes.Journal of psychosomatic research · 2023Trial
- Effects of a behavioral medicine intervention on pain, health, and behavior among community-dwelling older adults: a randomized controlled trial.Clinical interventions in aging · 2019Trial
- Risk of Incident Dry Eye Disease Among Patients With Chronic Pain Conditions.American journal of ophthalmology · 2026Article
- Symptom Networks in Postsurgical Cancer Pain Across Recovery Stages.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2026Observational
- Unveiling intervention targets: urban-rural disparities in depression-anxiety symptoms networks among Chinese older adults living alone.BMC geriatrics · 2026Article
- In the End: Associations Between Sleep Disturbance and Functional Impairment in Fibromyalgia-A Path Analysis Study.Journal of sleep research · 2026Article
- Article
- Nonlinear threshold and association of depressive symptoms with pain in middle-aged and older Chinese adults: a cross-sectional and cohort study.Scientific reports · 2026Article
- A review of neurophysiological relationships between sleep disorders and depression.Brain, behavior, & immunity - health · 2026Review
- Chronic pain in narcolepsy reflects interacting neurobiological and psychological mechanisms: a mini-review.Frontiers in sleep · 2026Review
- Genetic and Environmental Associations Among Pain, Sleep Disturbances, and Substance Use Intent in Early Adolescence.Journal of adolescence · 2026Article
- Risk factors associated with the co-occurrence of severe pain and sleep disturbance in oncology outpatients receiving chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Development and validation of a risk prediction model for co-existing depression in middle-aged and older adults with low back pain.European journal of medical research · 2025Article
94 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Epidemiological, cross-sectional, and prospective studies suggest that insomnia, chronic pain, and depression frequently co-occur and are mutually interacting conditions. However, the mechanisms underlying these comorbid disorders have yet to be elucidated. Overlapping mechanisms in the central nervous system suggest a common neurobiological substrate(s) may underlie the development and interplay of these disorders. We propose that the mesolimbic dopamine system is an underappreciated and attractive venue for the examination of neurobiological processes involved in the interactions, development, exacerbation, and maintenance of this symptom complex. In the present article, studies from multiple disciplines are reviewed to highlight the role of altered dopaminergic function in the promotion of arousal, pain sensitivity, and mood disturbance. We argue that studies aiming to elucidate common factors accounting for the comorbidity of insomnia, chronic pain, and depression should evaluate functioning within the mesolimbic dopaminergic system and its effect on common processes known to be dysregulated in all three disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.