ReviewTrends in neurosciences2012
Speed control: cogs and gears that drive the circadian clock.
Review in Trends in neurosciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 78 citations in OpenAlex.
- Splicing of a core circadian clock gene regulates seasonal adaptations by a winter gating mechanism.Science advances · 2026Article
- Microbe-dependent inter-organ communication regulates germline stem cell proliferation inbioRxiv : the preprint server for biology · 2026Article
- Splicing of a core clock gene regulates seasonal adaptations by a winter gating mechanism.bioRxiv : the preprint server for biology · 2025Article
- Article
- Epigenetic Mechanisms in the Transcriptional Regulation of Circadian Rhythm in Mammals.Biology · 2025Review
- In vivo functional significance of direct physical interaction between Period and Cryptochrome in mammalian circadian rhythm generation.PNAS nexus · 2024Article
- Mitochondrial inhibitors reveal roles of specific respiratory chain complexes in CRY-dependent degradation of TIM.Scientific reports · 2024Article
- Circadian Rhythm Regulation by Pacemaker Neuron Chloride Oscillation in Flies.Physiology (Bethesda, Md.) · 2024Review
- TARANIS Interacts with VRILLE and PDP1 to Modulate the Circadian Transcriptional Feedback Mechanism inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Many faces of sleep regulation: beyond the time of day and prior wake time.The FEBS journal · 2023Review
- Towards an Understanding of Circatidal Clocks.Frontiers in physiology · 2022Article
- Comparative transcriptome analysis and CRISPR/Cas9 gene editing reveal that E4BP4 mediates lithium upregulation ofOpen biology · 2021Article
- A global search for novel transcription factors impacting the Neurospora crassa circadian clock.G3 (Bethesda, Md.) · 2021Article
- SynGAP is expressed in the murine suprachiasmatic nucleus and regulates circadian-gated locomotor activity and light-entrainment capacity.The European journal of neuroscience · 2021Article
- The effect of the endosymbiont Wolbachia on the behavior of insect hosts.Insect science · 2020Review
- Identification of the Repressive Domain of the Negative Circadian Clock Component CHRONO.International journal of molecular sciences · 2020Article
- Molecular and circuit mechanisms mediating circadian clock output in the Drosophila brain.The European journal of neuroscience · 2020Review
- Splicing the Clock to Maintain and Entrain Circadian Rhythms.Journal of biological rhythms · 2019Review
- Role of Tau Protein in Remodeling of Circadian Neuronal Circuits and Sleep.Frontiers in aging neuroscience · 2019Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
In most organisms, an intrinsic circadian (~24-h) timekeeping system drives rhythms of physiology and behavior. Within cells that contain a circadian clock, specific transcriptional activators and repressors reciprocally regulate each other to generate a basic molecular oscillator. A mismatch of the period generated by this oscillator with the external environment creates circadian disruption, which can have adverse effects on neural function. Although several clock genes have been extensively characterized, a fundamental question remains: how do these genes work together to generate a ~24-h period? Period-altering mutations in clock genes can affect any of multiple regulated steps in the molecular oscillator. In this review, we examine the regulatory mechanisms that contribute to setting the pace of the circadian oscillator.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.