ArticleBioorganic & medicinal chemistry2012
DNA damage by C1027 involves hydrogen atom abstraction and addition to nucleobases.
Article in Bioorganic & medicinal chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Histone tails decrease N7-methyl-2'-deoxyguanosine depurination and yield DNA-protein cross-links in nucleosome core particles and cells.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Pyrimidine Nucleobase Radical Reactivity in DNA and RNA.Radiation physics and chemistry (Oxford, England : 1993) · 2016Article
- Reactivity of Nucleic Acid Radicals.Advances in physical organic chemistry · 2016Article
- Double-strand breaks from a radical commonly produced by DNA-damaging agents.Chemical research in toxicology · 2015Article
- The radiomimetic enediyne, 20'-deschloro-C-1027 induces inter-strand DNA crosslinks in hypoxic cells and overcomes cytotoxic radioresistance.DNA repair · 2014Article
- DNA damage by histone radicals in nucleosome core particles.Journal of the American Chemical Society · 2014Article
- 5,6-Dihydropyrimidine peroxyl radical reactivity in DNA.Journal of the American Chemical Society · 2014Article
- DNA double strand cleavage via interstrand hydrogen atom abstraction.Journal of the American Chemical Society · 2013Article
- Human DNA polymerase β, but not λ, can bypass a 2-deoxyribonolactone lesion together with proliferating cell nuclear antigen.ACS chemical biology · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
C1027 is a potent antitumor agent that damages DNA. It has the unusual ability to produce double strand breaks and interstrand cross-links (ICLs) intracellularly, which enable it to initiate concurrent ataxia-telangiestasia mutated (ATM) and Rad-3 related (ATR) independent damage responses. The latter form of damage is not well characterized. We have examined the effect of DNA sequence on C1027 reactivity and found it to be more diverse than previously thought. In addition, analysis of the chemical stability of ICLs suggests that they result from reaction with the deoxyribose ring on one strand but direct addition to a nucleobase on the opposite strand.
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Registered trials
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