ArticleBMC genomics2012
Evolutionary analysis of the ENTH/ANTH/VHS protein superfamily reveals a coevolution between membrane trafficking and metabolism.
Article in BMC genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Endosomal traffic disorders: a driving force behind neurodegenerative diseases.Translational neurodegeneration · 2024Review
- Genome-wide association mapping and genomic prediction for late blight and potato cyst nematode resistance in potato (Frontiers in plant science · 2023Article
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- Plant pathogens convergently evolved to counteract redundant nodes of an NLR immune receptor network.PLoS biology · 2021Article
- Attracted to membranes: lipid-binding domains in plants.Plant physiology · 2021Article
- Global Identification ofFrontiers in plant science · 2021Article
- Genetic control of tracheid properties in Norway spruce wood.Scientific reports · 2020Article
- Longin R-SNARE is retrieved from the plasma membrane by ANTH domain-containing proteins inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- EPSIN1 Modulates the Plasma Membrane Abundance of FLAGELLIN SENSING2 for Effective Immune Responses.Plant physiology · 2020Article
- Protein Amphipathic Helix Insertion: A Mechanism to Induce Membrane Fission.Frontiers in cell and developmental biology · 2019Review
- ANTH domain-containing proteins are required for the pollen tube plasma membrane integrity via recycling ANXUR kinases.Communications biology · 2018Article
- Structure and evolution of ENTH and VHS/ENTH-like domains in tepsin.Traffic (Copenhagen, Denmark) · 2017Article
- Phosphoinositides, Major Actors in Membrane Trafficking and Lipid Signaling Pathways.International journal of molecular sciences · 2017Review
- DEEPN as an Approach for Batch Processing of Yeast 2-Hybrid Interactions.Cell reports · 2016Article
- Clathrin binding by the adaptor Ent5 promotes late stages of clathrin coat maturation.Molecular biology of the cell · 2016Article
- Vestiges of Ent3p/Ent5p function in the giardial epsin homolog.Biochimica et biophysica acta · 2016Article
- Evolutionary Changes on the Way to Clathrin-Mediated Endocytosis in Animals.Genome biology and evolution · 2016Article
- ENTH and ANTH domain proteins participate in AP2-independent clathrin-mediated endocytosis.Journal of cell science · 2015Article
- Differential transcriptome analysis reveals insight into monosymmetric corolla development of the crucifer Iberis amara.BMC plant biology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMembrane trafficking involves the complex regulation of proteins and lipids intracellular localization and is required for metabolic uptake, cell growth and development. Different trafficking pathways passing through the endosomes are coordinated by the ENTH/ANTH/VHS adaptor protein superfamily. The endosomes are crucial for eukaryotes since the acquisition of the endomembrane system was a central process in eukaryogenesis.
resultsOur in silico analysis of this ENTH/ANTH/VHS superfamily, consisting of proteins gathered from 84 complete genomes representative of the different eukaryotic taxa, revealed that genomic distribution of this superfamily allows to discriminate Fungi and Metazoa from Plantae and Protists. Next, in a four way genome wide comparison, we showed that this discriminative feature is observed not only for other membrane trafficking effectors, but also for proteins involved in metabolism and in cytokinesis, suggesting that metabolism, cytokinesis and intracellular trafficking pathways co-evolved. Moreover, some of the proteins identified were implicated in multiple functions, in either trafficking and metabolism or trafficking and cytokinesis, suggesting that membrane trafficking is central to this co-evolution process.
conclusionsOur study suggests that membrane trafficking and compartmentalization were not only key features for the emergence of eukaryotic cells but also drove the separation of the eukaryotes in the different taxa.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.