ArticleNeural development2012
The atypical homeoprotein Pbx1a participates in the axonal pathfinding of mesencephalic dopaminergic neurons.
Article in Neural development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Netrin-1 signaling pathway mechanisms in neurodegenerative diseases.Neural regeneration research · 2025Article
- Comparative genomics sheds new light on the convergent evolution of infrared vision in snakes.Proceedings. Biological sciences · 2024Article
- PBX1: a TALE of two seasons-key roles during development and in cancer.Frontiers in cell and developmental biology · 2024Review
- Comprehensive summary: the role of PBX1 in development and cancers.Frontiers in cell and developmental biology · 2024Review
- Research progress of PBX1 in developmental and regenerative medicine.International journal of medical sciences · 2023Review
- FAN-C: a feature-rich framework for the analysis and visualisation of chromosome conformation capture data.Genome biology · 2020Article
- Yuan-Hu Zhi Tong Prescription Mitigates Tau Pathology and Alleviates Memory Deficiency in the Preclinical Models of Alzheimer's Disease.Frontiers in pharmacology · 2020Review
- Pitx3 and En1 determine the size and molecular programming of the dopaminergic neuronal pool.PloS one · 2017Article
- One more factor joins the plot: Pbx1 regulates differentiation and survival of midbrain dopaminergic neurons.The EMBO journal · 2016Article
- A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease.The EMBO journal · 2016Article
- Pbx1 is required for adult subventricular zone neurogenesis.Development (Cambridge, England) · 2016Article
- Efficient and biologically relevant consensus strategy for Parkinson's disease gene prioritization.BMC medical genomics · 2016Article
- Article
- Canonical BMP-Smad signalling promotes neurite growth in rat midbrain dopaminergic neurons.Neuromolecular medicine · 2014Article
- Gene expression patterns in the hippocampus during the development and aging of Glud1 (Glutamate Dehydrogenase 1) transgenic and wild type mice.BMC neuroscience · 2014Article
- A combinatorial regulatory signature controls terminal differentiation of the dopaminergic nervous system in C. elegans.Genes & development · 2013Article
- GSK3B and MAPT polymorphisms are associated with grey matter and intracranial volume in healthy individuals.PloS one · 2013Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe pre B-cell leukemia transcription factor 1 (Pbx1) genes belong to the three amino acid loop extension family of homeodomain proteins that form hetero-oligomeric complexes with other homeodomain transcription factors, thereby modulating target specificity, DNA binding affinity and transcriptional activity of their molecular associates.
resultsHere, we provide evidence that Pbx1 is expressed in mesencephalic dopaminergic neurons from embryonic day 11 into adulthood and determines some of the cellular properties of this neuronal population. In Pbx1-deficient mice, the mesencephalic dopaminergic axons stall during mid-gestation at the border between di- and telencephalon before entering the ganglionic eminence, leading to a loose organization of the axonal bundle and partial misrouting. In Pbx1-deficient dopaminergic neurons, the high affinity netrin-1 receptor, deleted in colon cancer (DCC), is down-regulated. Interestingly, we found several conserved Pbx1 binding sites in the first intron of DCC, suggesting a direct regulation of DCC transcription by Pbx1.
conclusionsThe expression of Pbx1 in dopaminergic neurons and its regulation of DCC expression make it an important player in defining the axonal guidance of the midbrain dopaminergic neurons, with possible implications for the normal physiology of the nigro-striatal system as well as processes related to the degeneration of neurons during the course of Parkinson's disease.
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