ArticleBMC genomics2012
Comparative transcriptome analysis between planarian Dugesia japonica and other platyhelminth species.
Article in BMC genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Transcription Factors Active in the Anterior Blastema ofBiomolecules · 2021Article
- Alternative Animal Models of Aging Research.Frontiers in molecular biosciences · 2021Review
- The pharyngeal nervous system orchestrates feeding behavior in planarians.Science advances · 2020Article
- JmjC Domain-Encoding Genes Are Conserved in Highly Regenerative Metazoans and Are Associated with Planarian Whole-Body Regeneration.Genome biology and evolution · 2019Article
- Girardia dorotocephala transcriptome sequence, assembly, and validation through characterization of piwi homologs and stem cell progeny markers.Developmental biology · 2018Article
- Draft genome ofZoological letters · 2018Article
- The protein subunit of telomerase displays patterns of dynamic evolution and conservation across different metazoan taxa.BMC evolutionary biology · 2017Article
- Cysteine and Aspartyl Proteases Contribute to Protein Digestion in the Gut of Freshwater Planaria.PLoS neglected tropical diseases · 2016Article
- Two distinct roles of the yorkie/yap gene during homeostasis in the planarian Dugesia japonica.Development, growth & differentiation · 2015Article
- Functional analysis of Girardia tigrina transcriptome seeds pipeline for anthelmintic target discovery.Parasites & vectors · 2015Article
- Unusually Large Number of Mutations in Asexually Reproducing Clonal Planarian Dugesia japonica.PloS one · 2015Article
- iTRAQ-Based Quantitative Proteomic Analysis of the Initiation of Head Regeneration in Planarians.PloS one · 2015Article
- On-chip immobilization of planarians for in vivo imaging.Scientific reports · 2014Article
- Ca²⁺ channels and praziquantel: a view from the free world.Parasitology international · 2013Review
- RNA interference by feeding in vitro-synthesized double-stranded RNA to planarians: methodology and dynamics.Developmental dynamics : an official publication of the American Association of Anatomists · 2013Article
- Screening for neurotoxic potential of 15 flame retardants using freshwater planarians.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlanarians are considered to be among the extant animals close to one of the earliest groups of organisms that acquired a central nervous system (CNS) during evolution. Planarians have a bilobed brain with nine lateral branches from which a variety of external signals are projected into different portions of the main lobes. Various interneurons process different signals to regulate behavior and learning/memory. Furthermore, planarians have robust regenerative ability and are attracting attention as a new model organism for the study of regeneration. Here we conducted large-scale EST analysis of the head region of the planarian Dugesia japonica to construct a database of the head-region transcriptome, and then performed comparative analyses among related species.
resultsA total of 54,752 high-quality EST reads were obtained from a head library of the planarian Dugesia japonica, and 13,167 unigene sequences were produced by de novo assembly. A new method devised here revealed that proteins related to metabolism and defense mechanisms have high flexibility of amino-acid substitutions within the planarian family. Eight-two CNS-development genes were found in the planarian (cf. C. elegans 3; chicken 129). Comparative analysis revealed that 91% of the planarian CNS-development genes could be mapped onto the schistosome genome, but one-third of these shared genes were not expressed in the schistosome.
conclusionsWe constructed a database that is a useful resource for comparative planarian transcriptome studies. Analysis comparing homologous genes between two planarian species showed that the potential of genes is important for accumulation of amino-acid substitutions. The presence of many CNS-development genes in our database supports the notion that the planarian has a fundamental brain with regard to evolution and development at not only the morphological/functional, but also the genomic, level. In addition, our results indicate that the planarian CNS-development genes already existed before the divergence of planarians and schistosomes from their common ancestor.
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