ArticleBMC genomics2012
Transcriptome analysis reveals novel patterning and pigmentation genes underlying Heliconius butterfly wing pattern variation.
Article in BMC genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Differences in structural color and population genetic structure of Western and Central Palearctic Polyommatus icarus populations.Scientific reports · 2026Article
- WntA expression and wing transcriptomics illuminate the evolution of stripe patterns in skipper butterflies.Biology open · 2025Article
- Article
- aristaless1 has a dual role in appendage formation and wing color specification during butterfly development.BMC biology · 2023Article
- Review
- Heliconius butterflies: a window into the evolution and development of diversity.Current opinion in genetics & development · 2021Review
- Cell Dissociation from Butterfly Pupal Wing Tissues for Single-Cell RNA Sequencing.Methods and protocols · 2020Article
- Parallel evolution of ancient, pleiotropic enhancers underlies butterfly wing pattern mimicry.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Conservation and flexibility in the gene regulatory landscape of heliconiine butterfly wings.EvoDevo · 2019Article
- Longwing (Heliconius) butterflies combine a restricted set of pigmentary and structural coloration mechanisms.BMC evolutionary biology · 2017Article
- Single master regulatory gene coordinates the evolution and development of butterfly color and iridescence.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Comparative transcriptomes and reciprocal best hit analysis revealed potential pigment genes in two color forms of Tetranychus urticae.Experimental & applied acarology · 2017Article
- orco Mutagenesis Causes Loss of Antennal Lobe Glomeruli and Impaired Social Behavior in Ants.Cell · 2017Article
- Genetic Basis of Melanin Pigmentation in Butterfly Wings.Genetics · 2017Article
- Gene co-expression network connectivity is an important determinant of selective constraint.PLoS genetics · 2017Article
- Waiting in the wings: what can we learn about gene co-option from the diversification of butterfly wing patterns?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Regulatory Architecture of Gene Expression Variation in the Threespine Stickleback Gasterosteus aculeatus.G3 (Bethesda, Md.) · 2017Article
- Article
- Transcriptome analysis of the painted lady butterfly, Vanessa cardui during wing color pattern development.BMC genomics · 2016Article
- Positional cloning of a Bombyx pink-eyed white egg locus reveals the major role of cardinal in ommochrome synthesis.Heredity · 2016Article
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8 authors.
Funding
Abstract
backgroundHeliconius butterfly wing pattern diversity offers a unique opportunity to investigate how natural genetic variation can drive the evolution of complex adaptive phenotypes. Positional cloning and candidate gene studies have identified a handful of regulatory and pigmentation genes implicated in Heliconius wing pattern variation, but little is known about the greater developmental networks within which these genes interact to pattern a wing. Here we took a large-scale transcriptomic approach to identify the network of genes involved in Heliconius wing pattern development and variation. This included applying over 140 transcriptome microarrays to assay gene expression in dissected wing pattern elements across a range of developmental stages and wing pattern morphs of Heliconius erato.
resultsWe identified a number of putative early prepattern genes with color-pattern related expression domains. We also identified 51 genes differentially expressed in association with natural color pattern variation. Of these, the previously identified color pattern "switch gene" optix was recovered as the first transcript to show color-specific differential expression. Most differentially expressed genes were transcribed late in pupal development and have roles in cuticle formation or pigment synthesis. These include previously undescribed transporter genes associated with ommochrome pigmentation. Furthermore, we observed upregulation of melanin-repressing genes such as ebony and Dat1 in non-melanic patterns.
conclusionsThis study identifies many new genes implicated in butterfly wing pattern development and provides a glimpse into the number and types of genes affected by variation in genes that drive color pattern evolution.
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