ArticleNutrition journal2012
Associations between toenail arsenic concentration and dietary factors in a New Hampshire population.
Article in Nutrition journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Toenails as a biomarker of exposure to arsenic: A review.Environmental research · 2021Pooled it
- Associations between a mixture of trace elements and bladder cancer occurrence: A study of possible reverse causation.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- High-Dietary Fiber Diet Reduces Arsenic Oral Bioavailability and Health Risk from Soils by Regulating Gut Microbiota and Intestinal Barrier Function.Foods (Basel, Switzerland) · 2026Article
- Disease-associated metabolic pathways affected by heavy metals and metalloid.Toxicology reports · 2023Review
- Exposure to arsenolipids and inorganic arsenic from marine-sourced dietary supplements.Chemosphere · 2022Article
- Influence of Dietary Compounds on Arsenic Metabolism and Toxicity. Part II-Human Studies.Toxics · 2021Review
- Urinary total arsenic and arsenic methylation capacity in pregnancy and gestational diabetes mellitus: A case-control study.Chemosphere · 2021Article
- Toenail metal concentrations and age at menopause: A prospective study.Environmental epidemiology (Philadelphia, Pa.) · 2020Article
- Early-Life Arsenic Exposure, Nutritional Status, and Adult Diabetes Risk.Current diabetes reports · 2019Review
- The role of arsenic in obesity and diabetes.Journal of cellular physiology · 2019Review
- Serum homocysteine, arsenic methylation, and arsenic-induced skin lesion incidence in Bangladesh: A one-carbon metabolism candidate gene study.Environment international · 2018Article
- Rice Consumption and Squamous Cell Carcinoma of the Skin in a United States Population.Environmental health perspectives · 2017Article
- Maternal blood cadmium, lead and arsenic levels, nutrient combinations, and offspring birthweight.BMC public health · 2017Article
- Associations between Diet and Toenail Arsenic Concentration among Pregnant Women in Bangladesh: A Prospective Study.Nutrients · 2017Article
- Frequency of M287T/AS3MT Single Nucleotide Polymorphism in an Iranian Population.International journal of hematology-oncology and stem cell research · 2017Article
- Arsenic exposure is associated with diminished insulin sensitivity in non-diabetic Amish adults.Diabetes/metabolism research and reviews · 2016Article
- Biological and behavioral factors modify urinary arsenic metabolic profiles in a U.S. population.Environmental health : a global access science source · 2016Article
- Applying the Bradford Hill criteria in the 21st century: how data integration has changed causal inference in molecular epidemiology.Emerging themes in epidemiology · 2015Article
- The mechanistic basis of arsenicosis: pathogenesis of skin cancer.Cancer letters · 2014Review
- Inverse association between toenail arsenic and body mass index in a population of welders.Environmental research · 2014Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDietary factors such as folate, vitamin B12, protein, and methionine are important for the excretion of arsenic via one-carbon metabolism in undernourished populations exposed to high levels of arsenic via drinking water. However, the effects of dietary factors on toenail arsenic concentrations in well-nourished populations exposed to relatively low levels of water arsenic are unknown.
methodsAs part of a population-based case-control study of skin and bladder cancer from the USA, we evaluated relationships between consumption of dietary factors and arsenic concentrations in toenail clippings. Consumption of each dietary factor was determined from a validated food frequency questionnaire. We used general linear models to examine the associations between toenail arsenic and each dietary factor, taking into account potentially confounding effects.
resultsAs expected, we found an inverse association between ln-transformed toenail arsenic and consumption of vitamin B12 (excluding supplements) and animal protein. Unexpectedly, there were also inverse associations with numerous dietary lipids (e.g., total fat, total animal fat, total vegetable fat, total monounsaturated fat, total polyunsaturated fat, and total saturated fat). Finally, increased toenail arsenic concentrations were associated with increased consumption of long chain n-3 fatty acids.
conclusionIn a relatively well-nourished population exposed to relatively low levels of arsenic via water, consumption of certain dietary lipids may decrease toenail arsenic concentration, while long chain n-3 fatty acids may increase toenail arsenic concentration, possibly due to their association with arsenolipids in fish tissue.
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