ArticleGenome biology2012
Whole-genome sequencing and analysis of the Malaysian cynomolgus macaque (Macaca fascicularis) genome.
Article in Genome biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Global spatiotemporal patterns of demographic fluctuations in terrestrial vertebrates during the Late Pleistocene.Science advances · 2025Article
- Genomic Evidence for the Complex Evolutionary History of Macaques (Genus Macaca).Journal of molecular evolution · 2024Article
- DNA methylation and transcriptome analysis reveal epigenomic differences among three macaque species.Evolutionary applications · 2024Article
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- Gene editing monkeys: Retrospect and outlook.Frontiers in cell and developmental biology · 2022Review
- Genomic Copy Number Variation Study of Nine Macaca Species Provides New Insights into Their Genetic Divergence, Adaptation, and Biomedical Application.Genome biology and evolution · 2020Article
- Primate phylogenomics uncovers multiple rapid radiations and ancient interspecific introgression.PLoS biology · 2020Article
- Rhesus macaques as a tractable physiological model of human ageing.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- MACSNVdb: a high-quality SNV database for interspecies genetic divergence investigation among macaques.Database : the journal of biological databases and curation · 2020Article
- Whole-Genome Resequencing of TwentyBioMed research international · 2020Article
- Functional genomics of simian malaria parasites and host-parasite interactions.Briefings in functional genomics · 2019Review
- Cynomolgus macaque IL37 polymorphism and control of SIV infection.Scientific reports · 2019Article
- Translational animal models for endometriosis research: a long and windy road.Annals of translational medicine · 2018Article
- Gene expression dataset for whole cochlea of Macaca fascicularis.Scientific reports · 2018Article
- Comparative genome-wide survey of single nucleotide variation uncovers the genetic diversity and potential biomedical applications among six Macaca species.International journal of molecular sciences · 2018Article
- Spontaneous endometriosis in cynomolgus monkeys as a clinically relevant experimental model.Human reproduction (Oxford, England) · 2018Article
- Whole genome sequencing in the search for genes associated with the control of SIV infection in the Mauritian macaque model.Scientific reports · 2018Article
- Article
- Genomic Tools for the Use of Nonhuman Primates in Translational Research.ILAR journal · 2017Review
- Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe genetic background of the cynomolgus macaque (Macaca fascicularis) is made complex by the high genetic diversity, population structure, and gene introgression from the closely related rhesus macaque (Macaca mulatta). Herein we report the whole-genome sequence of a Malaysian cynomolgus macaque male with more than 40-fold coverage, which was determined using a resequencing method based on the Indian rhesus macaque genome.
resultsWe identified approximately 9.7 million single nucleotide variants (SNVs) between the Malaysian cynomolgus and the Indian rhesus macaque genomes. Compared with humans, a smaller nonsynonymous/synonymous SNV ratio in the cynomolgus macaque suggests more effective removal of slightly deleterious mutations. Comparison of two cynomolgus (Malaysian and Vietnamese) and two rhesus (Indian and Chinese) macaque genomes, including previously published macaque genomes, suggests that Indochinese cynomolgus macaques have been more affected by gene introgression from rhesus macaques. We further identified 60 nonsynonymous SNVs that completely differentiated the cynomolgus and rhesus macaque genomes, and that could be important candidate variants for determining species-specific responses to drugs and pathogens. The demographic inference using the genome sequence data revealed that Malaysian cynomolgus macaques have experienced at least three population bottlenecks.
conclusionsThis list of whole-genome SNVs will be useful for many future applications, such as an array-based genotyping system for macaque individuals. High-quality whole-genome sequencing of the cynomolgus macaque genome may aid studies on finding genetic differences that are responsible for phenotypic diversity in macaques and may help control genetic backgrounds among individuals.
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