ArticleBMC microbiology2012
Variation of chemosensory receptor content of Campylobacter jejuni strains and modulation of receptor gene expression under different in vivo and in vitro growth conditions.
Article in BMC microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Identification of a dCache-type chemoreceptor inFrontiers in microbiology · 2024Article
- A Guideline for Assessment and Characterization of Bacterial Biofilm Formation in the Presence of Inhibitory Compounds.Bio-protocol · 2023Article
- Bacterial chemotaxis in human diseases.Trends in microbiology · 2023Review
- Diverse Sensory Repertoire of Paralogous Chemoreceptors Tlp2, Tlp3, and Tlp4 inMicrobiology spectrum · 2022Article
- Polar localization of CheO under hypoxia promotes Campylobacter jejuni chemotactic behavior within host.PLoS pathogens · 2022Article
- Extracellular c-di-GMP Plays a Role in Biofilm Formation and Dispersion ofMicroorganisms · 2022Article
- TheScience signaling · 2021Article
- Inhibition ofAntibiotics (Basel, Switzerland) · 2020Article
- Structure-Activity Relationship Study Reveals the Molecular Basis for Specific Sensing of Hydrophobic Amino Acids by theBiomolecules · 2020Article
- Article
- The transducer-like protein Tlp12 of Campylobacter jejuni is involved in glutamate and pyruvate chemotaxis.BMC microbiology · 2018Article
- A peculiar case of Campylobacter jejuni attenuated aspartate chemosensory mutant, able to cause pathology and inflammation in avian and murine model animals.Scientific reports · 2018Article
- Transducer-Like Protein inFrontiers in microbiology · 2018Article
- Campylobacter jejuni transducer like proteins: Chemotaxis and beyond.Gut microbes · 2017Review
- Metabolic and fitness determinants for in vitro growth and intestinal colonization of the bacterial pathogen Campylobacter jejuni.PLoS biology · 2017Article
- Dissecting the Interplay Between Intestinal Microbiota and Host Immunity in Health and Disease: Lessons Learned from Germfree and Gnotobiotic Animal Models.European journal of microbiology & immunology · 2016Review
- A direct-sensing galactose chemoreceptor recently evolved in invasive strains of Campylobacter jejuni.Nature communications · 2016Article
- Association ofEuropean journal of microbiology & immunology · 2016Article
- Cloning, refolding, purification and preliminary crystallographic analysis of the sensory domain of the Campylobacter chemoreceptor for multiple ligands (CcmL).Acta crystallographica. Section F, Structural biology communications · 2015Article
- Transducer like proteins of Campylobacter jejuni 81-176: role in chemotaxis and colonization of the chicken gastrointestinal tract.Frontiers in cellular and infection microbiology · 2015Article
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8 authors.
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Abstract
backgroundChemotaxis is crucial for the colonisation/infection of hosts with Campylobacter jejuni. Central to chemotaxis are the group A chemotaxis genes that are responsible for sensing the external environment. The distribution of group A chemoreceptor genes, as found in the C. jejuni sequenced strains, tlp1-4, 7, 10 and 11 were determined in 33 clinical human and avian isolates.
resultsGroup A tlp gene content varied among the strains with genes encoding tlp1 (aspartate receptor, ccaA) and tlp7 present in all strains tested, where as tlp11 was present in only one of our international collection clinical isolates, C. jejuni 520, but was more prevalent (9/13) in the freshly isolated clinical stains from patients who required hospitalisation due to C. jejuni infection (GCH1-17). Relative expression levels of the group A tlp genes were also determined in C. jejuni reference strains NCTC 11168-GS, 11168-O and 81116 using cells grown in vitro at 37°C, 42°C and maintained at room temperature and with cells isolated directly from murine and avian hosts by immune magnetic separation without subsequent culture. Gene expression of tlp genes was varied based on strain, growth conditions and in vivo isolation source. Tlp1, although the most conserved, showed the lowest and most varied mRNA expression and protein production under laboratory conditions. Tlp7 was highly expressed at most conditions tested, and gene expression was not influenced by the tlp7 gene encoding a full length protein or one expressed as separate periplasmic and cytoplasmic domains.
conclusionWe have shown that chemosensory receptor set variation exists among C. jejuni strains, but is not dependent on the isolation source.
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