ArticleDiabetes technology & therapeutics2012
The effect of tubing dwell time on insulin adsorption during intravenous insulin infusions.
Article in Diabetes technology & therapeutics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Polyvinyl chloride-related insulin adsorption in critical care: a narrative review with implications for patient safety and green hospital reform.Frontiers in medicine · 2026Review
- A proof of principle study using radiopharmaceuticals to quantify and localize container-content interactions in medical syringes.Scientific reports · 2023Article
- Clinical Recommendations for Managing the Impact of Insulin Adsorptive Loss in Hospital and Diabetes Care.Journal of diabetes science and technology · 2021Article
- Addition of Regular Insulin to Ternary Parenteral Nutrition: A Stability Study.Pharmaceutics · 2021Article
- Capacity of Infusion Lines for Insulin Adsorption: Effect of Flow Rate on Total Adsorption.Journal of diabetes science and technology · 2021Article
- Updates in the Management of Hyperglycemic Crisis.Frontiers in clinical diabetes and healthcare · 2021Review
- Quantitative assessment of required separator fluid volume in multi-infusion settings.The journal of vascular access · 2020Article
- Impact of alternative materials to plasticized PVC infusion tubings on drug sorption and plasticizer release.Scientific reports · 2019Article
- Do bevacizumab solutions interact with silicone or polyurethane catheters during an infusion through implantable venous access ports?Journal of the Royal Society, Interface · 2019Article
- Effect of Tubing Flush or Preconditioning on Available Insulin Concentration for IV Infusion: A Pilot Project.The Canadian journal of hospital pharmacyArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundInsulin adsorbs to plastic tubing, which decreases the concentration of an insulin solution delivered from an intravenous infusion set. Dwelling insulin within tubing before starting the infusion decreases adsorption but delays treatment initiation and wastes time in infusion preparation. The lack of data on dwell time effects results in wide variability in practice. We aim to determine the effect of dwell time on insulin concentration from intravenous infusion tubing. MATERIALS AND
methodsIn this in vitro study, we used insulin solutions with concentrations of 0.1 unit/mL, 1 unit/mL, and 10 units/mL. Each solution dwelled in intravenous infusion sets for 0, 15, 30, or 60 min. After the dwell, we measured insulin concentrations from the solution bags and tubing. We repeated each insulin concentration-dwell time combination five times. Comparisons were performed using analyses of variance.
resultsFor each of the three insulin concentrations, the mean insulin concentrations from the tubing were not significantly different between dwell times. Duration of dwell time did not affect insulin adsorption in polypropylene intravenous infusion sets.
conclusionsWe recommend that following a 20-mL flush, insulin infusions can be started without any dwell time. Removal of dwell times may improve clinical practice by minimizing preparation time and will allow faster initiation of insulin infusion therapy.
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