ArticleOrganic letters2012
One-pot, two-step cascade synthesis of quinazolinotriazolobenzodiazepines.
Article in Organic letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Synthetic aspects of 1,4- and 1,5-benzodiazepines usingRSC advances · 2023Review
- Synthesis and biological evaluation of the new ring system benzo[RSC advances · 2021Article
- Metal-free synthesis of 1,4-benzodiazepines and quinazolinones from hexafluoroisopropyl 2-aminobenzoates at room temperature.RSC advances · 2021Article
- One-Pot Synthesis of Triazolobenzodiazepines Through Decarboxylative [3 + 2] Cycloaddition of Nonstabilized Azomethine Ylides and Cu-Free Click Reactions.Molecules (Basel, Switzerland) · 2019Article
- Transition metal-free one-pot synthesis of nitrogen-containing heterocycles.Molecular diversity · 2016Review
- Expedient one-pot synthesis of indolo[3,2-Tetrahedron letters · 2015Article
- Efficient Cu(OTf)2-catalyzed synthesis of novel and diverse 2,3-dihydroquinazolin-4(1H)-ones.Molecular diversity · 2015Article
- Facile one-pot assembly of imidazotriazolobenzodiazepines via indium(III)-catalyzed multicomponent reactions.Organic letters · 2013Article
- Microwave-assisted three-component domino reaction: Synthesis of indolodiazepinotriazoles.Beilstein journal of organic chemistry · 2013Article
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3 authors.
Funding
Abstract
An operationally simple, one-pot, two-step cascade method has been developed to afford quinazolino[1,2,3]triazolo[1,4]benzodiazepines. This unique, atom-economical transformation engages five reactive centers (amide, aniline, carbonyl, azide, and alkyne) and employs environmentally benign iodine as a catalyst. The method proceeds via sequential quinazolinone-forming condensation and intramolecular azide-alkyne 1,3-dipolar cycloaddition reactions. Substrate scope, multicomponent examples, and mechanistic insights are discussed.
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