ArticlePloS one2012
Transcriptional profiling of serogroup B Neisseria meningitidis growing in human blood: an approach to vaccine antigen discovery.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Biochemical and structural characterization of meningococcal methylenetetrahydrofolate reductase.Protein science : a publication of the Protein Society · 2023Article
- Article
- Article
- Establishing the critical role of peripheral blood vessel colonisation by Neisseria meningitidis in invasive meningococcal disease.Virulence · 2017Article
- The Hfq regulon ofFEBS open bio · 2017Article
- Inactivation ofInfection and immunity · 2017Article
- Comparative proteomic analysis of Neisseria meningitidis wildtype and dprA null mutant strains links DNA processing to pilus biogenesis.BMC microbiology · 2017Article
- Transcriptomic buffering of cryptic genetic variation contributes to meningococcal virulence.BMC genomics · 2017Article
- UnravelingF1000Research · 2017Review
- Article
- HexR Controls Glucose-Responsive Genes and Central Carbon Metabolism in Neisseria meningitidis.Journal of bacteriology · 2015Article
- Metabolism and virulence in Neisseria meningitidis.Frontiers in cellular and infection microbiology · 2014Review
- Transcriptional profiling of Neisseria meningitidis interacting with human epithelial cells in a long-term in vitro colonization model.Infection and immunity · 2013Article
- Review
- Analysis of the regulated transcriptome of Neisseria meningitidis in human blood using a tiling array.Journal of bacteriology · 2012Article
Corrections and comments
- Erratum issued
- Erratum issuedHedman, Asa K [corrected to Hedman, Åsa K]
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Neisseria meningitidis is a nasopharyngeal commensal of humans which occasionally invades the blood to cause septicaemia. The transcriptome of N. meningitidis strain MC58 grown in human blood for up to 4 hours was determined and around 10% of the genome was found to be differentially regulated. The nuo, pet and atp operons, involved in energy metabolism, were up-regulated, while many house-keeping genes were down-regulated. Genes encoding protein chaperones and proteases, involved in the stress response; complement resistant genes encoding enzymes for LOS sialylation and biosynthesis; and fHbp (NMB1870) and nspA (NMB0663), encoding vaccine candidates, were all up-regulated. Genes for glutamate uptake and metabolism, and biosynthesis of purine and pyrimidine were also up-regulated. Blood grown meningococci are under stress and undergo a metabolic adaptation and energy conservation strategy. The localisation of four putative outer membrane proteins encoded by genes found to be up-regulated in blood was assessed by FACS using polyclonal mouse antisera, and one (NMB0390) showed evidence of surface expression, supporting its vaccine candidacy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.