ArticlePloS one2012
Proton-coupled electron-transfer mechanism for the radical scavenging activity of cardiovascular drug dipyridamole.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 18 citations in OpenAlex.
- Effect of Dipyridamole on Membrane Energization and Energy Transfer in Chromatophores of Rba. sphaeroides.Biochemistry. Biokhimiia · 2022Article
- Generation of radical form of dipyridamole at illumination of photosynthetic reaction centers of Rb. sphaeroides.Doklady. Biochemistry and biophysics · 2017Article
- Antioxidant activity of polyphenolic myricetin in vitro cell- free and cell-based systems.Molecular biology research communications · 2016Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dipyridamole (DIP) is a well-known pharmaceutical drug used as a coronary vasodilator and anti-platelet agent in clinics for treating several cardiovascular diseases. Primarily, the therapeutic effects of the drug are attributed to its antioxidant potency. In this research, we aim to declare the unknown antioxidant mechanism of DIP as well as its potent chain-breaking antioxidant activity in polar aqueous medium inside the cells, using different experimental methods and theoretical quantum calculations. Data demonstrated the higher antioxidant capacity of DIP against ROS and free radicals in polar cell's interior. DIP is capable of generating long living and noninvasive DIP(•) radicals in oxidant condition that leads to an effective "chain-breaking antioxidant" activity. Quantum computational data indicated that DIP antioxidant has more favorable ionization potential than trolox which means DIP has higher antioxidant activity. Also, data showed that the direct hydrogen-transfer is not a favorable process to construct DIP(•) because of high barrier energy, though electron-transfer process can more easily to produce DIP(•+) with the lowest barrier energy. Altogether, the electron donating potency of DIP to reduce ferric ion, having the low anodic oxidation peak potential, producing long lived stable DIP(•) radicals and protecting myoblast cells from oxidation, proposed the excellent "chain-breaking antioxidant" potency via electron-transfer mechanism of this vasodilator DIP drug in polar aqueous medium.
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