ArticlePloS one2012
CC8 MRSA strains harboring SCCmec type IVc are predominant in Colombian hospitals.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Community-genotype methicillin-resistant Staphylococcus aureus skin and soft tissue infections in Latin America: a systematic review.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesPooled it
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- Methicillin-resistantCurrent pharmaceutical biotechnology · 2025Review
- JR20, a novel natural product-derived compound, exhibits potent anti-biofilm activity against methicillin-resistantFrontiers in microbiology · 2025Article
- Molecular Characteristics of Community-Acquired Methicillin-ResistantIndian journal of microbiology · 2024Article
- Historic methicillin-resistant Staphylococcus aureus: expanding current knowledge using molecular epidemiological characterization of a Swiss legacy collection.Genome medicine · 2024Article
- Epidemiological and microbiological characteristics ofFrontiers in pediatrics · 2024Article
- A Novel Strategy to Identify Endolysins with Lytic Activity against Methicillin-ResistantInternational journal of molecular sciences · 2023Article
- Inhibition of Erythromycin and Erythromycin-Induced Resistance amongAntibiotics (Basel, Switzerland) · 2023Article
- Article
- Genotypic Characterization of Clinical Isolates ofPathogens (Basel, Switzerland) · 2021Article
- Molecular and Anti-Microbial Resistance (AMR) Profiling of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2021Article
- Molecular Epidemiology ofAntibiotics (Basel, Switzerland) · 2020Review
- Control of Methicillin-ResistantFrontiers in microbiology · 2020Article
- Methicillin-ResistantThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2019Article
- Observational
- Emergence and spread of a new community-genotype methicillin-resistant Staphylococcus aureus clone in Colombia.BMC infectious diseases · 2017Article
- Detection of diverse genotypes of Methicillin-resistantAntimicrobial resistance and infection control · 2017Article
- Staphylococcal Cassette Chromosome mec Types Among Methicillin-ResistantJundishapur journal of microbiology · 2016Article
- Parallel Epidemics of Community-Associated Methicillin-Resistant Staphylococcus aureus USA300 Infection in North and South America.The Journal of infectious diseases · 2015Article
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Authors and funding
16 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent reports highlight the incursion of community-associated MRSA within healthcare settings. However, knowledge of this phenomenon remains limited in Latin America. The aim of this study was to evaluate the molecular epidemiology of MRSA in three tertiary-care hospitals in Medellín, Colombia.
methodsAn observational cross-sectional study was conducted from 2008-2010. MRSA infections were classified as either community-associated (CA-MRSA) or healthcare-associated (HA-MRSA), with HA-MRSA further classified as hospital-onset (HAHO-MRSA) or community-onset (HACO-MRSA) according to standard epidemiological definitions established by the U.S. Centers for Disease Control and Prevention (CDC). Genotypic analysis included SCCmec typing, spa typing, PFGE and MLST.
resultsOut of 538 total MRSA isolates, 68 (12.6%) were defined as CA-MRSA, 243 (45.2%) as HACO-MRSA and 227 (42.2%) as HAHO-MRSA. The majority harbored SCCmec type IVc (306, 58.7%), followed by SCCmec type I (174, 33.4%). The prevalence of type IVc among CA-, HACO- and HAHO-MRSA isolates was 92.4%, 65.1% and 43.6%, respectively. From 2008 to 2010, the prevalence of type IVc-bearing strains increased significantly, from 50.0% to 68.2% (p = 0.004). Strains harboring SCCmec IVc were mainly associated with spa types t1610, t008 and t024 (MLST clonal complex 8), while PFGE confirmed that the t008 and t1610 strains were closely related to the USA300-0114 CA-MRSA clone. Notably, strains belonging to these three spa types exhibited high levels of tetracycline resistance (45.9%).
conclusionCC8 MRSA strains harboring SCCmec type IVc are becoming predominant in Medellín hospitals, displacing previously reported CC5 HA-MRSA clones. Based on shared characteristics including SCCmec IVc, absence of the ACME element and tetracycline resistance, the USA300-related isolates in this study are most likely related to USA300-LV, the recently-described 'Latin American variant' of USA300.
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