ArticlePLoS biology2012
Reversing the outcome of synapse elimination at developing neuromuscular junctions in vivo: evidence for synaptic competition and its mechanism.
Article in PLoS biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed.
- Connectomic evidence that ordered activity drives neuromuscular network formation.Nature neuroscience · 2026Article
- Early postsynaptic instability and acetylcholine receptor compartmentalization precede neuromuscular synapse dismantling.Communications biology · 2026Article
- The neuromuscular junction: a critical component of functional recovery after peripheral nerve injury.Frontiers in surgery · 2026Review
- Neddylation E1 Obligatory Subunit Nae1 Is Critical to Neuromuscular Junction Development and Maintenance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Skeletal muscle reprogramming enhances reinnervation after peripheral nerve injury.Nature communications · 2024Article
- A neural algorithm for computing bipartite matchings.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Skeletal muscle reprogramming enhances reinnervation after peripheral nerve injury.Research square · 2024Article
- The times they are a-changin': a proposal on how brain flexibility goes beyond the obvious to include the concepts of "upward" and "downward" to neuroplasticity.Molecular psychiatry · 2023Review
- Dissection, in vivo imaging and analysis of the mouse epitrochleoanconeus muscle.Journal of anatomy · 2022Article
- The impact of neuron morphology on cortical network architecture.Cell reports · 2022Article
- Completion of neuronal remodeling prompts myelination along developing motor axon branches.The Journal of cell biology · 2021Article
- Motor function recovery: deciphering a regenerative niche at the neuromuscular synapse.Biological reviews of the Cambridge Philosophical Society · 2021Review
- [Youth and Alcohol : A survey with a view to the situation in Austria].Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2020Article
- Primary and secondary motoneurons use different calcium channel types to control escape and swimming behaviors in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Morphological variability is greater at developing than mature mouse neuromuscular junctions.Journal of anatomy · 2020Article
- Synaptic Plasticity Induced by Differential Manipulation of Tonic and Phasic Motoneurons inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Developmental neuromuscular synapse elimination: Activity-dependence and potential downstream effector mechanisms.Neuroscience letters · 2020Review
- Article
- Terminal Schwann cell and vacant site mediated synapse elimination at developing neuromuscular junctions.Scientific reports · 2019Article
- Spontaneity Assessment in Dually Innervated Gracilis Smile Reanimation Surgery.JAMA facial plastic surgery · 2019Article
Corrections and comments
- Commented on by
Authors and funding
2 authors.
Funding
Abstract
During mammalian development, neuromuscular junctions and some other postsynaptic cells transition from multiple- to single-innervation as synaptic sites are exchanged between different axons. It is unclear whether one axon invades synaptic sites to drive off other inputs or alternatively axons expand their territory in response to sites vacated by other axons. Here we show that soon-to-be-eliminated axons rapidly reverse fate and grow to occupy vacant sites at a neuromuscular junction after laser removal of a stronger input. This reversal supports the idea that axons take over sites that were previously vacated. Indeed, during normal development we observed withdrawal followed by takeover. The stimulus for axon growth is not postsynaptic cell inactivity because axons grow into unoccupied sites even when target cells are functionally innervated. These results demonstrate competition at the synaptic level and enable us to provide a conceptual framework for understanding this form of synaptic plasticity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.