ArticleEuropean journal of inorganic chemistry2012
Structure - relaxivity relationships among targeted MR contrast agents.
Article in European journal of inorganic chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Evolving Characteristics of Gadolinium-Based Contrast Agents for MR Imaging: A Systematic Review of the Importance of Relaxivity.Journal of magnetic resonance imaging : JMRI · 2025Pooled it
- Morphology Effect of PEGylated Iron Oxide Nanoparticles on the Enhancement of MRI Contrast Signal in Breast Cancer.ACS applied materials & interfaces · 2025Article
- Geometry and Surface Area Optimization in Iron Oxide Nanoparticles for Enhanced Magnetic Properties.ACS omega · 2024Article
- Structure-Relaxivity Relationships of Magnetic Nanoparticles for Magnetic Resonance Imaging.Advanced materials (Deerfield Beach, Fla.) · 2019Review
- Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.Chemical reviews · 2019Review
- Hydration number: crucial role in nuclear magnetic relaxivity of Gd(III) chelate-based nanoparticles.Scientific reports · 2017Article
- Crosslinked shells for nano-assembled capsules: a new encapsulation method for smaller GdChemical communications (Cambridge, England) · 2017Article
- Enhancing magnetic resonance imaging with contrast agents for ultra-high field strengths.The Analyst · 2014Review
- Binding of a dimeric manganese porphyrin to serum albumin: towards a gadolinium-free blood-pool T1 MRI contrast agent.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2014Article
- Lanthanide(III) complexes of rhodamine-DO3A conjugates as agents for dual-modal imaging.Inorganic chemistry · 2013Article
- Coupling fast water exchange to slow molecular tumbling in Gd3+ chelates: why faster is not always better.Inorganic chemistry · 2013Article
- Introductory Chemistry: A Molar Relaxivity Experiment in the High School Classroom.Journal of chemical education · 2013Article
- Characterization of estrogen-receptor-targeted contrast agents in solution, breast cancer cells, and tumors in vivo.Magnetic resonance in medicine · 2013Article
- The importance of water exchange rates in the design of responsive agents for MRI.Current opinion in chemical biology · 2013Review
- Structure-relaxivity relationships of serum albumin targeted MRI probes based on a single amino acid Gd complex.Journal of medicinal chemistry · 2013Article
- Gd(DOTAla): a single amino acid Gd-complex as a modular tool for high relaxivity MR contrast agent development.Journal of the American Chemical Society · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Paramagnetic gadolinium(III) complexes are widely used to increase contrast in magnetic resonance (MR) images. Contrast enhancement depends on the concentration of the gadolinium complex and on its relaxivity, an inherent property of the complex. Increased relaxivity results in greater image contrast or the ability to detect the contrast agent at a lower concentration. Increasing relaxivity enables imaging of abundant molecular targets.Relaxivity depends on the structure of the complex, kinetics of inner-sphere and second sphere water exchange, and on the rotational dynamics of the molecule. The latter, and in some cases the former, properties of the complex change when it is bound to its target. All of these properties can be rationally tuned to enhance relaxivitry. In this Microreview we summarize our efforts in understanding and optimizing the relaxivity of contrast agents targeted to serum albumin and to fibrin.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.