ArticleEvolutionary bioinformatics online2012
Evolution of the RALF Gene Family in Plants: Gene Duplication and Selection Patterns.
Article in Evolutionary bioinformatics online, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed, 114 citations in OpenAlex.
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- Genome-wide identification and expression analysis of HMAs gene family in tobacco under abiotic stress.Scientific reports · 2026Article
- Molecular mimicry and trafficking of peptide effectors in sedentary nematodes: emerging drivers of feeding site formation and host signaling hijack.Crop health · 2026Review
- The RALF-FERONIA Signaling Axis: A Central Hub Integrating Plant Growth, Reproduction, and Stress Responses.International journal of molecular sciences · 2025Review
- Polyploidization-driven formation of theScience advances · 2025Article
- A molecular perspective on the role of FERONIA in root growth, nutrient uptake, stress sensing and microbiome assembly.Journal of advanced research · 2025Review
- Genome-Wide Characterization ofInternational journal of molecular sciences · 2025Article
- Article
- Genome-wide exploration and characterization of the RALFs and analysis of its role in peanut (Arachis hypogaea L.).BMC plant biology · 2025Article
- RALF-FER, a master ligand‒receptor pair in plant health.Crop health · 2025Review
- Peptide hormones in plants.Molecular horticulture · 2025Review
- Article
- Peptides in plant reproduction-small yet powerful.Frontiers in plant science · 2025Review
- Genome-wide identification and functional validation of RLCK VII subfamily genes conferring disease resistance in broad bean (Frontiers in plant science · 2025Article
- Characterization of fatty acid desaturase gene family inFrontiers in plant science · 2025Article
- Genome-Wide Identification of thePlants (Basel, Switzerland) · 2024Article
- RALF proteins-a monitoring hub for regulating salinity tolerance in plants.Frontiers in plant science · 2024Article
- Comprehensive identification, characterization and expression analyses of the class III POD gene family in water lily (Frontiers in plant science · 2024Article
- Identification and characterization of ACR gene family in maize for salt stress tolerance.Frontiers in plant science · 2024Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rapid alkalinization factors (RALFs) are plant small peptides that could induce a rapid pH increase in the medium of plant cell suspension culture and play a critical role in plant development. The evolutionary process of the RALF gene family remains unclear. To obtain details of the phylogeny of these genes, this study characterized RALF genes in Arabidopsis, rice, poplar and maize. Phylogenetic trees, evolutionary patterns and molecular evolutionary rates were used to elucidate the evolutionary process of this gene family. In addition, the different signatures of selection, expression patterns, and subcellular localization of RALFs were also analyzed. We found that the RALF gene family had a rapid birth process after the separation of the eudicot and monocot species about 145 million years ago, that tandem duplication played a dominant role in the expansion of Arabidopsis and rice RALF gene family, and that RALFs were under purifying selection according to estimations of the substitution rates of these genes. We also identified a diverse expression pattern of RALF genes and predominant extracellular localization feature of RALF proteins. Our findings shed light on several key differences in RALF gene family evolution among the plant species, which may provide a scaffold for future functional analysis of this family.
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