ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Early formation of GABAergic synapses governs the development of adult-born neurons in the olfactory bulb.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 48 citations in OpenAlex.
- New Neurons in the Postnatal Olfactory System: Functions in the Healthy and Regenerating Brain.Brain sciences · 2025Review
- Signaling mechanisms underlying activity-dependent integration of adult-born neurons in the mouse olfactory bulb.Genesis (New York, N.Y. : 2000) · 2024Review
- Olfactory neurogenesis plays different parts at successive stages of life, implications for mental health.Frontiers in neural circuits · 2024Review
- Transcriptome Analysis Reveals Olfactory System Expression Characteristics of Aquatic Snakes.Frontiers in genetics · 2022Article
- Diversity and function of corticopetal and corticofugal GABAergic projection neurons.Nature reviews. Neuroscience · 2020Review
- Microglial depletion disrupts normal functional development of adult-born neurons in the olfactory bulb.eLife · 2020Article
- GABAergic Input From the Basal Forebrain Promotes the Survival of Adult-Born Neurons in the Mouse Olfactory Bulb.Frontiers in neural circuits · 2020Article
- Diazepam Inhibits Post-Traumatic Neurogenesis and Blocks Aberrant Dendritic Development.Journal of neurotrauma · 2019Article
- The role of calretinin-expressing granule cells in olfactory bulb functions and odor behavior.Scientific reports · 2018Article
- Article
- Inhibitory circuits of the mammalian main olfactory bulb.Journal of neurophysiology · 2017Review
- RhoGEF9 splice isoforms influence neuronal maturation and synapse formation downstream of α2 GABAA receptors.PLoS genetics · 2017Article
- Prodepressant- and anxiogenic-like effects of serotonin-selective, but not noradrenaline-selective, antidepressant agents in mice lacking α2-containing GABABehavioural brain research · 2017Article
- Plasticity in the olfactory bulb of the maternal mouse is prevented by gestational stress.Scientific reports · 2016Article
- Principal cell activity induces spine relocation of adult-born interneurons in the olfactory bulb.Nature communications · 2016Article
- Anxiety- and Depression-Like States Lead to Pronounced Olfactory Deficits and Impaired Adult Neurogenesis in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Rapid Feedforward Inhibition and Asynchronous Excitation Regulate Granule Cell Activity in the Mammalian Main Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- BDNF over-expression increases olfactory bulb granule cell dendritic spine density in vivo.Neuroscience · 2015Article
- Dendrodendritic synapses in the mouse olfactory bulb external plexiform layer.The Journal of comparative neurology · 2015Article
- Molecular Mechanisms Regulating the Dendritic Development of Newborn Olfactory Bulb Interneurons in a Sensory Experience-Dependent Manner.Frontiers in neuroscience · 2015Review
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Authors and funding
7 authors at 4 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In mammals, olfactory bulb granule cells (GCs) are generated throughout life in the subventricular zone. GABAergic inputs onto newborn neurons likely regulate their maturation, but the details of this process remain still elusive. Here, we investigated the differentiation, synaptic integration, and survival of adult-born GCs when their afferent GABAergic inputs are challenged by conditional gene targeting. Migrating GC precursors were targeted with Cre-eGFP-expressing lentiviral vectors in mice with a floxed gene encoding the GABA(A) receptor α2-subunit (i.e., Gabra2). Ablation of the α2-subunit did not affect GC survival but dramatically delayed their maturation. We found a reduction in postsynaptic α2-subunit and gephyrin clusters accompanied by a decrease in the frequency and amplitude of GABAergic postsynaptic currents beginning ∼14 d post-injection (dpi). In addition, mutant cells exhibited altered dendritic branching and spine density. Spine loss appeared with mislocation of glutamatergic synapses on dendritic shafts and a reduction of spontaneous glutamatergic postsynaptic currents, underscoring the relevance of afferent GABAergic transmission for a proper synaptic integration of newborn GCs. To test the role of GABAergic signaling during much early stages of GC maturation, we used a genetic strategy to selectively inactivate Gabra2 in precursor cells of the subventricular zone. In these mice, labeling of newborn GCs with eGFP lentiviruses revealed similar morphological alterations as seen on delayed Gabra2 inactivation in migrating neuroblasts, with reduced dendritic branching and spine density at 7 dpi. Collectively, these results emphasize the critical role of GABAergic synaptic signaling for structural maturation of adult-born GCs and formation of glutamatergic synapses.
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