ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Two forms of learning following training to a single odorant in Caenorhabditis elegans AWC neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed.
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- Extracellular vesicles aid in the transfer of long-term associative memory betweenResearch square · 2025Article
- Extracellular vesicles aid in the transfer of long-term associative memory betweenbioRxiv : the preprint server for biology · 2025Article
- The C. elegans glutamate transporters GLT-4 and GLT-5 regulate protein expression, behavior, and lifespan.Neurochemistry international · 2025Article
- Chemical basis of microbiome preference in the nematode C. elegans.Scientific reports · 2024Article
- The G protein alpha chaperone and guanine-nucleotide exchange factor RIC-8 regulates cilia morphogenesis in Caenorhabditis elegans sensory neurons.PLoS genetics · 2023Article
- Inhibition of the expression of rgs-3 alleviates propofol-induced decline in learning and memory in Caenorhabditis elegans.CNS neuroscience & therapeutics · 2023Article
- Arrestin-mediated desensitization enables intraneuronal olfactory discrimination inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- OLA-1, an Obg-like ATPase, integrates hunger with temperature information in sensory neurons in C. elegans.PLoS genetics · 2022Article
- Differential Regulation of Innate and Learned Behavior byThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- A Memory Circuit for Coping with Impending Adversity.Current biology : CB · 2019Article
- Neurotransmitter signaling through heterotrimeric G proteins: insights from studies in C. elegans.WormBook : the online review of C. elegans biology · 2018Review
- Mutations in the guanylate cyclase gcy-28 neuronally dissociate naïve attraction and memory retrieval.The European journal of neuroscience · 2018Article
- Phospholipase D functional ablation has a protective effect in an Alzheimer's disease Caenorhabditis elegans model.Scientific reports · 2018Article
- Identification of attractive odorants released by preferred bacterial food found in the natural habitats of C. elegans.PloS one · 2018Article
- Article
- C. elegans positive olfactory associative memory is a molecularly conserved behavioral paradigm.Neurobiology of learning and memory · 2014Article
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- The Intersection of Aging, Longevity Pathways, and Learning and Memory in C. elegans.Frontiers in genetics · 2012Article
- A Receptor Tyrosine Kinase Plays Separate Roles in Sensory Integration and Associative Learning ineNeuroArticle
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The nematode Caenorhabditis elegans can adapt to both the AWC-sensed odorants benzaldehyde (Bnz) and isoamyl alcohol (IsoA) and can reciprocally cross-adapt. Yet we reveal that these four adaptation scenarios actually represent two distinct forms of learning: nonassociative habituation and associative learning by pairing with a starvation unconditioned stimulus. Training to the single odorant IsoA leads to both associative and nonassociative memory traces, which can be preferentially accessed by either a Bnz or IsoA retrieval stimulus, respectively. This represents the first demonstration in which the form of learning displayed after training to a single stimulus is a function of the retrieval stimulus used. Furthermore, these two forms of learning can be genetically double dissociated despite both forms occurring within the AWC primary sensory neuron. We find that associative learning requires the cGMP-dependent kinase egl-4 and insulin signaling, which acts downstream of egl-4. In contrast, nonassociative learning requires neither of these genes, but does require the TRPV channel osm-9, which is dispensable for associative learning. In addition, we find that the arrestin arr-1 is promiscuous between associative and nonassociative learning in mediating the adaptive response to the IsoA retrieval stimulus, suggesting that distinct forms of memory may nonetheless use common downstream effectors.
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