ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Threat of punishment motivates memory encoding via amygdala, not midbrain, interactions with the medial temporal lobe.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Choosing certainty over risk: Associations of PTSD symptom severity with memory sampling during experiential decision making.Journal of anxiety disorders · 2025Article
- The effects of auditory consequences on visuomotor adaptation and motor memory.Experimental brain research · 2024Article
- Threat impairs flexible use of a cognitive map.Motivation and emotion · 2023Article
- Conscious expectancy rather than associative strength elicits brain activity during single-cue fear conditioning.Social cognitive and affective neuroscience · 2023Article
- Instructed motivational states bias reinforcement learning and memory formation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Tag and capture: how salient experiences target and rescue nearby events in memory.Trends in cognitive sciences · 2022Review
- Functional activation of insula and dorsal anterior cingulate for conflict control against larger monetary loss in young adults with subthreshold depression: a preliminary study.Scientific reports · 2022Article
- A Systematic Approach to Neuropsychiatric Intervention: Functional Neuroanatomy Underlying Symptom Domains as Targets for Treatment.Focus (American Psychiatric Publishing) · 2022Review
- Memory consolidation as an adaptive process.Psychonomic bulletin & review · 2021Review
- Effective connectivity underlying reward-based executive control.Human brain mapping · 2021Article
- Punishment-modulated attentional capture is context specific.Motivation science · 2021Article
- Semantic generalization of punishment-related attentional priority.Visual cognition · 2021Article
- Measuring attention to reward as an individual trait: the value-driven attention questionnaire (VDAQ).Psychological research · 2020Article
- Amygdala and ventral tegmental area differentially interact with hippocampus and cortical medial temporal lobe during rest in humans.Hippocampus · 2020Article
- Article
- The influence of threat and aversive motivation on conflict processing in the Stroop task.Attention, perception & psychophysics · 2020Article
- Threat reduces value-driven but not salience-driven attentional capture.Emotion (Washington, D.C.) · 2020Article
- Punishment-related memory-guided attention: Neural dynamics of perceptual modulation.Cortex; a journal devoted to the study of the nervous system and behavior · 2019Article
- Differential impact of reward and punishment on functional connectivity after skill learning.NeuroImage · 2019Article
- Differential modulation of cognitive control networks by monetary reward and punishment.Social cognitive and affective neuroscience · 2019Article
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3 authors.
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Abstract
Neural circuits associated with motivated declarative encoding and active threat avoidance have both been described, but the relative contribution of these systems to punishment-motivated encoding remains unknown. The current study used functional magnetic resonance imaging in humans to examine mechanisms of declarative memory enhancement when subjects were motivated to avoid punishments that were contingent on forgetting. A motivational cue on each trial informed participants whether they would be punished or not for forgetting an upcoming scene image. Items associated with the threat of shock were better recognized 24 h later. Punishment-motivated enhancements in subsequent memory were associated with anticipatory activation of right amygdala and increases in its functional connectivity with parahippocampal and orbitofrontal cortices. On a trial-by-trial basis, right amygdala activation during the motivational cue predicted hippocampal activation during encoding of the subsequent scene; across participants, the strength of this interaction predicted memory advantages due to motivation. Of note, punishment-motivated learning was not associated with activation of dopaminergic midbrain, as would be predicted by valence-independent models of motivation to learn. These data are consistent with the view that motivation by punishment activates the amygdala, which in turn prepares the medial temporal lobe for memory formation. The findings further suggest a brain system for declarative learning motivated by punishment that is distinct from that for learning motivated by reward.
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