ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Period coding of Bmal1 oscillators in the suprachiasmatic nucleus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Attractive and repulsive couplings between circadian pacemaker neurons promote entrainment to light-dark cycles with after-effect.Npj biological timing and sleep · 2026Article
- Interpretable machine learning reveals hemispheric asymmetry of state switching in the suprachiasmatic nucleus.Patterns (New York, N.Y.) · 2026Article
- Diet-responsive proteogenomic effects following short-term restriction of animal products in humans.Nature communications · 2026Article
- Toward dissection of diverse neural components in the suprachiasmatic nucleus (SCN) pacemaker network.Neurobiology of sleep and circadian rhythms · 2026Article
- Neuronal feedback loop of the suprachiasmatic nucleus generates robust circadian rhythms.Nature communications · 2026Article
- Modeling the geometry of circadian synchronization and period across aging.Biogerontology · 2025Article
- Neuropeptidergic Input from the Lateral Hypothalamus to the Suprachiasmatic Nucleus Alters the Circadian Period in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Secretome from estrogen-responding human placenta-derived mesenchymal stem cells rescues ovarian function and circadian rhythm in mice with cyclophosphamide-induced primary ovarian insufficiency.Journal of biomedical science · 2024Article
- Enhancing Bioluminescence Imaging of Cultured Tissue Explants Using Optical Telecompression.Sensors (Basel, Switzerland) · 2024Article
- The seasons within: a theoretical perspective on photoperiodic entrainment and encoding.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Review
- The Suprachiasmatic Nucleus at 50: Looking Back, Then Looking Forward.Journal of biological rhythms · 2024Review
- Weak synchronization can alter circadian period length: implications for aging and disease conditions.Frontiers in neuroscience · 2023Article
- Retina-attached slice recording reveals light-triggered tonic GABA signaling in suprachiasmatic nucleus.Molecular brain · 2021Article
- Daily coordination of orexinergic gating in the rat superior colliculus-Implications for intrinsic clock activities in the visual system.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Timed daily exercise remodels circadian rhythms in mice.Communications biology · 2021Article
- Seasonality and light phase-resetting in the mammalian circadian rhythm.Scientific reports · 2020Article
- Nonlinear phenomena in models of the circadian clock.Journal of the Royal Society, Interface · 2020Article
- Seasonally variant gene expression in full-term human placenta.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- The Excitatory Effects of GABA within the Suprachiasmatic Nucleus: Regulation of Na-K-2Cl Cotransporters (NKCCs) by Environmental Lighting Conditions.Journal of biological rhythms · 2020Article
- Timekeeping in the hindbrain: a multi-oscillatory circadian centre in the mouse dorsal vagal complex.Communications biology · 2020Article
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Authors and funding
6 authors.
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Abstract
Circadian oscillators in the suprachiasmatic nucleus (SCN) collectively orchestrate 24 h rhythms in the body while also coding for seasonal rhythms. Although synchronization is required among SCN oscillators to provide robustness for regular timekeeping (Herzog et al., 2004), heterogeneity of period and phase distributions is needed to accommodate seasonal variations in light duration (Pittendrigh and Daan, 1976b). In the mouse SCN, the heterogeneous phase distribution has been recently found in the cycling of clock genes Period 1 and Period 2 (Per1, Per2) and has been shown to reorganize by relative day lengths (Inagaki et al., 2007). However, it is not yet clearly understood what underlies the spatial patterning of Per1 and Per2 expression (Yamaguchi et al., 2003; Foley et al., 2011) and its plasticity. We found that the period of the oscillation in Bmal1 expression, a positive-feedback component of the circadian clock, preserves the behavioral circadian period under culture and drives clustered oscillations in the mouse SCN. Pharmacological and physical isolations of SCN subregions indicate that the period of Bmal1 oscillation is subregion specific and is preserved during culture. Together with computer simulations, we show that either the intercellular coupling does not strongly influence the Bmal1 oscillation or the nature of the coupling is more complex than previously assumed. Furthermore, we have found that the region-specific periods are modulated by the light conditions that an animal is exposed to. Based on these, we suggest that the period forms the basis of seasonal coding in the SCN.
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