Trial reportClinical journal of the American Society of Nephrology : CJASN2012
The association between exit site infection and subsequent peritonitis among peritoneal dialysis patients.
Trial report in Clinical journal of the American Society of Nephrology : CJASN, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 4 syntheses or guidelines pooled it, 133 citations in OpenAlex.
- Exit-site infection and subsequent incident risk of peritoneal dialysis-associated peritonitis: a retrospective cohort study with meta-analysis.Frontiers in public health · 2026Pooled it
- Effect of different exit-site care dressings on preventing peritoneal dialysis related infection from nontropical area: a systematic review and network meta-analysis.Renal failure · 2024Pooled it
- Antimicrobial agents for preventing peritonitis in peritoneal dialysis patients.The Cochrane database of systematic reviews · 2017Pooled it
- A qualitative systematic review of the literature supporting a causal relationship between exit-site infection and subsequent peritonitis in patients with end-stage renal disease treated with peritoneal dialysis.Peritoneal dialysis international : journal of the International Society for Peritoneal DialysisPooled it
- Trial
- Negative-pressure wound therapy is effective for peritoneal dialysis catheter exit-site management in the early postoperative period.Scientific reports · 2022Trial
- Sex-Specific Outcomes in the Peritoneal Dialysis Outcomes and Practice Patterns Study.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Xerosis elevates the risk of catheter-related infections in peritoneal dialysis patients.Kidney research and clinical practice · 2026Article
- Efficacy of topical treatment for fungal peritoneal dialysis exit-site infection (ESI).BMC nephrology · 2026Article
- Peritoneal Dialysis-RelatedClinical case reports · 2026Article
- Relapsing peritoneal dialysis‑associated peritonitis caused by Pseudomonas oryzihabitans with concurrent tunnel infection: a case report and literature review.CEN case reports · 2026Review
- Improvement in peritoneal dialysis exit-site infection rates in an integrated health care system in the United States.Frontiers in nephrology · 2026Article
- Modifiable risk factors for peritoneal dialysis-related infections - a population-based cohort study on risk factors and outcomes in South Sweden.Frontiers in nephrology · 2025Article
- Tunnel ultrasound can guide the use of peritoneal dialysis catheter exit site relocation by external splicing and cuff removal in refractory tunnel infection.International urology and nephrology · 2024Article
- Risk factors of peritoneal dialysis-related peritonitis in the Japan Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS).Clinical kidney journal · 2024Article
- Efficacy of sucrose and povidone-iodine mixtures in peritoneal dialysis catheter exit-site care.BMC nephrology · 2024Observational
- Article
- Utility of ultrasonographic examination in catheter-related infections in peritoneal dialysis: a clinical approach.Journal of nephrology · 2023Review
- The use of mini-invasive surgical techniques to treat refractory exit-site and tunnel infections in peritoneal dialysis patients: a clinical approach.Journal of nephrology · 2023Review
- Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesPeritonitis is the most common infectious complication seen in peritoneal dialysis (PD). Traditionally, exit site infection (ESI) has been thought to predispose PD patients to peritonitis, although the risks have not been quantified. This study aimed to quantify the risk of PD peritonitis after ESI. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Data from 203 clinically stable PD patients >18 years of age who were followed as part of a randomized controlled trial over 18 months were used to estimate the risk of developing peritonitis within 30 days of an ESI compared with individuals who did not have a recent ESI. Sensitivity analyses were performed at 15, 45, and 60 days.
resultsPatients were mostly male (64.5%) and Caucasian, with a mean age of 60.5 ± 14.4 years. There were 44 ESIs and 87 peritonitis episodes during the 18-month study. Seven patients had an ESI followed by peritonitis within 30 days. Using a frailty model, patients who had an ESI had a significantly higher risk of developing peritonitis within 30 days, even if the ESI was appropriately treated. This risk was maximal early on and diminished with time, with hazard ratios (95% confidence interval) of 11.1 at 15 days (HR=11.1, 95% CI=4.9-25.1), 5.3 at 45 days (2.5-11.3), and 4.9 at 60 days (2.4-9.9). In 2.3% of patients, subsequent peritonitis was caused by the same organism as the previous ESI.
conclusionsA strong association between a treated ESI and subsequent PD peritonitis was present up to 60 days after initial diagnosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.