Evidence map›Paper›PMID 22745116›Full record

Trial reportAnesthesia and analgesia2012

Continuous femoral nerve blocks: the impact of catheter tip location relative to the femoral nerve (anterior versus posterior) on quadriceps weakness and cutaneous sensory block.

Brian M Ilfeld, Vanessa J Loland, NavParkash S Sandhu, Preetham J Suresh, Michael J Bishop, Michael C Donohue, Eliza J Ferguson, Sarah J Madison

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Anesthesia and analgesia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01759277 (Femoral Versus Adductor Canal Continuous Peripheral Nerve Blocks for Knee Arthroplasty), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01759277 phase4completednot on this map

Femoral Versus Adductor Canal Continuous Peripheral Nerve Blocks for Knee Arthroplasty

TypeinterventionalSponsorUniversity of California, San DiegoRan2012 to 2014Enrolled80ConditionsPostoperative Pain Following Knee ArthroplastyArmsControl: Femoral perineural local anesthetic infusion, Experimental: Adductor Canal perineural local anesthetic infusion
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Brian M IlfeldDepartment of Anesthesiology, University of California San Diego, San Diego, CA 92103-8770, USA. bilfeld@ucsd.edu
Vanessa J Loland
NavParkash S Sandhu
Preetham J Suresh
Michael J Bishop
Michael C Donohue
Eliza J Ferguson
Sarah J Madison
University of California, San Diego · US

Funding

SAN DIEGO CLINICAL AND TRANSLATIONAL RESEARCH INSTITUTEUL1RR031980 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2010 to 2011
$14.0M
Perineural Anesthetic Infusion After Joint ReplacementK23GM077026 · NIGMS · UNIVERSITY OF FLORIDA · PI ILFELD, BRIAN M · 2005 to 2009
$617k
NCRR NIH HHS UL1 RR031980NCRR NIH HHS UL1RR031980NIGMS NIH HHS GM077026NIGMS NIH HHS K23 GM077026
6 · The paper itself

Abstract

backgroundDuring a continuous femoral nerve block, the influence of catheter tip position relative to the femoral nerve on infusion characteristics remains unknown.

methodsWe inserted bilateral femoral perineural catheters in volunteers (ultrasound-guided, needle in-plane). Subjects' dominant side was randomized to have the catheter tip placed either anterior or posterior to the femoral nerve. The contralateral limb received the alternative position. Ropivacaine 0.1% was administered through both catheters concurrently for 6 hours (4 mL/h). Outcome measures included the maximum voluntary isometric contraction (MVIC) of the quadriceps femoris muscle and tolerance to cutaneous electrical current over to the distal quadriceps tendon. Measurements were performed at hour 0 (baseline), and on the hour until hour 9, as well as hour 22. The primary end point was the MVIC of the quadriceps at hour 6.

resultsAs a percentage of the baseline measurement, quadriceps MVIC for limbs with anterior (n = 16) and posterior (n = 16) catheter tip placement did not differ to a statistically significant degree at hour 6 (mean [SD] 29% [26] vs 30% [28], respectively; 95% confidence interval: -22% to 20%; P = 0.931), or at any other time point. However, the maximum tolerance to cutaneous electrical current was higher in limbs with anterior compared with posterior catheter tip placement at hour 6 (20 [23] mA vs 6 [4] mA, respectively; 95% confidence interval: 1-27 mA; P = 0.035), as well as at hours 1, 7, 8, and 9 (P < 0.04).

conclusionsThis study documents the significant (70%-80%) quadriceps femoris weakness induced by a continuous femoral nerve block infusion at a relatively low dose of ropivacaine (4 mg/h) delivered through a perineural catheter located both anterior and posterior to the femoral nerve. In contrast, an anterior placement increases cutaneous sensory block compared with a posterior insertion, without a concurrent relative increase in motor block.

Indexed as

AdultCatheterizationFemaleFemoral NerveHumansMaleMuscle WeaknessNerve BlockProspective StudiesSkinYoung Adult

Identifiers

PMID22745116
PMCPMC3425725
OpenAlexW2154536903

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.