ArticleArthritis care & research2013
Influence of ethnicity on childhood-onset systemic lupus erythematosus: results from a multiethnic multicenter Canadian cohort.
Article in Arthritis care & research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review of rheumatic disease phenotypes and outcomes in the Indigenous populations of Canada, the USA, Australia and New Zealand.Rheumatology international · 2017Pooled it
- Characterizing lupus in African American children in Southern United States.Pediatric rheumatology online journal · 2025Article
- Outcomes of achieving lupus low disease activity state and damage accrual in childhood-onset systemic lupus erythematosus.Clinical rheumatology · 2023Article
- Infection-related hospitalisation in young adults with systemic lupus erythematosus: data from the National Inpatient Sample.Lupus science & medicine · 2023Article
- High Disease Severity Among Asian Patients in a US Multiethnic Cohort of Individuals With Systemic Lupus Erythematosus.Arthritis care & research · 2022Article
- Disease characteristics in patients with juvenile- and adult-onset systemic lupus erythematosus: A multi-center comparative study.Archives of rheumatology · 2022Article
- Article
- Disease presentation of 1312 childhood-onset systemic lupus erythematosus: influence of ethnicity.Clinical rheumatology · 2019Article
- Long-Term Clinical Outcomes in a Cohort of Adults With Childhood-Onset Systemic Lupus Erythematosus.Arthritis & rheumatology (Hoboken, N.J.) · 2019Article
- Systemic Lupus Erythematosus in Primary Care: An Update and Practical Messages for the General Practitioner.Frontiers in medicine · 2018Review
- Advances in the care of children with lupus nephritis.Pediatric research · 2017Review
- Spectrum of paediatric rheumatic diseases in Nigeria.Pediatric rheumatology online journal · 2017Article
- Autoantigen microarrays reveal autoantibodies associated with proliferative nephritis and active disease in pediatric systemic lupus erythematosus.Arthritis research & therapy · 2015Article
- Association of health-related quality of life in childhood-onset systemic lupus erythematosus with ethnicity: results from a multiethnic multicenter Canadian cohort.Arthritis care & research · 2014Article
- National trends in pediatric systemic lupus erythematosus hospitalization in the United States: 2000-2009.The Journal of rheumatology · 2014Article
- Article
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Authors and funding
8 authors.
Funding
Abstract
objectiveTo determine the influence of ethnicity and sociodemographic factors on disease characteristics of the Canadian pediatric lupus population.
methodsChildhood-onset systemic lupus erythematosus (SLE) patients at 4 pediatric centers in Halifax, Montreal, Toronto, and Vancouver were consecutively recruited. Sociodemographics and disease data were collected. Patients were categorized by their primary self-selected ethnicity, and exploratory cluster analyses were examined for disease expression by ethnicity.
resultsWe enrolled 213 childhood-onset SLE patients, and ethnicity data were available for 206 patients: white (31%), Asian (30%), South Asian (15%), black (10%), Latino/Hispanic (4%), Aboriginal (4%), and Arab/Middle Eastern (3%). The frequency of clinical classification criteria (malar rash, arthritis, serositis, and renal disease) and autoantibodies significantly differed among ethnicities. Medications were prescribed equally across ethnicities: 76% were taking prednisone, 86% antimalarials, and 56% required additional immunosuppressants. Cluster analysis partitioned into 3 main groups: mild (n = 50), moderate (n = 82), and severe (n = 68) disease clusters. Only 20% of white patients were in the severe cluster compared to 51% of Asian and 41% of black patients (P = 0.03). However, disease activity indices and damage scores were similar across ethnicities.
conclusionCanadian childhood-onset SLE patients reflect our multiethnic population, with differences in disease manifestations, autoantibody profiles, and severity of disease expression by ethnicity.
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