ReviewBiomechanics and modeling in mechanobiology2012
Mechanotransduction in embryonic vascular development.
Review in Biomechanics and modeling in mechanobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed.
- Kidney organoid vascularization: current advancements in the field.Regenerative therapy · 2026Article
- Aberrant Subclavian Artery in Interrupted Aortic Arch with Severe Aortic Outlet Obstruction: Cerebral Blood Flow as a Possible Determinant of Embryonic Cardiovascular Development?Pediatric cardiology · 2025Article
- Controversy in mechanotransduction - the role of endothelial cell-cell junctions in fluid shear stress sensing.Journal of cell science · 2024Article
- Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets.Signal transduction and targeted therapy · 2023Review
- On the role of mechanical signals on sprouting angiogenesis through computer modeling approaches.Biomechanics and modeling in mechanobiology · 2022Review
- Rethinking growth factors: the case of BMP9 during vessel maturation.Vascular biology (Bristol, England) · 2022Review
- Article
- Developmental origins of mechanical homeostasis in the aorta.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Article
- Mechanoregulation of Vascular Endothelial Growth Factor Receptor 2 in Angiogenesis.Frontiers in cardiovascular medicine · 2021Review
- Endothelial cell polarization and orientation to flow in a novel microfluidic multimodal shear stress generator.Lab on a chip · 2020Article
- Article
- Advanced microscopy to elucidate cardiovascular injury and regeneration: 4D light-sheet imaging.Progress in biophysics and molecular biology · 2018Review
- Computational modelling suggests complex interactions between interstitial flow and tumour angiogenesis.Journal of the Royal Society, Interface · 2018Article
- Flow-Responsive Vascular Endothelial Growth Factor Receptor-Protein Kinase C Isoform Epsilon Signaling Mediates Glycolytic Metabolites for Vascular Repair.Antioxidants & redox signaling · 2018Article
- Live imaging molecular changes in junctional tension upon VE-cadherin in zebrafish.Nature communications · 2017Article
- Endothelial cells respond to the direction of mechanical stimuli through SMAD signaling to regulate coronary artery size.Development (Cambridge, England) · 2017Article
- Time-Series Interactions of Gene Expression, Vascular Growth and Hemodynamics during Early Embryonic Arterial Development.PloS one · 2016Article
- Growth and hemodynamics after early embryonic aortic arch occlusion.Biomechanics and modeling in mechanobiology · 2015Article
- Genetic variation in the functional ENG allele inherited from the non-affected parent associates with presence of pulmonary arteriovenous malformation in hereditary hemorrhagic telangiectasia 1 (HHT1) and may influence expression of PTPN14.Frontiers in genetics · 2015Article
- Chronic intrauterine pulmonary hypertension increases main pulmonary artery stiffness and adventitial remodeling in fetal sheep.American journal of physiology. Lung cellular and molecular physiology · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
A plethora of biochemical signals provides spatial and temporal cues that carefully orchestrate the complex process of vertebrate embryonic development. The embryonic vasculature develops not only in the context of these biochemical cues, but also in the context of the biomechanical forces imparted by blood flow. In the mature vasculature, different blood flow regimes induce distinct genetic programs, and significant progress has been made toward understanding how these forces are perceived by endothelial cells and transduced into biochemical signals. However, it cannot be assumed that paradigms that govern the mature vasculature are pertinent to the developing embryonic vasculature. The embryonic vasculature can respond to the mechanical forces of blood flow, and these responses are critical in vascular remodeling, certain aspects of sprouting angiogenesis, and maintenance of arterial-venous identity. Here, we review data regarding mechanistic aspects of endothelial cell mechanotransduction, with a focus on the response to shear stress, and elaborate upon the multifarious effects of shear stress on the embryonic vasculature. In addition, we discuss emerging predictive vascular growth models and highlight the prospect of combining signaling pathway information with computational modeling. We assert that correlation of precise measurements of hemodynamic parameters with effects on endothelial cell gene expression and cell behavior is required for fully understanding how blood flow-induced loading governs normal vascular development and shapes congenital cardiovascular abnormalities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.