ArticleNeuroradiology2012
Effectiveness of four different clinical fMRI paradigms for preoperative regional determination of language lateralization in patients with brain tumors.
Article in Neuroradiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Utilization of functional MRI language paradigms for pre-operative mapping: a systematic review.Neuroradiology · 2020Pooled it
- American Society of Functional Neuroradiology-Recommended fMRI Paradigm Algorithms for Presurgical Language Assessment.AJNR. American journal of neuroradiology · 2017Guideline
- Comparing the Intracarotid Amobarbital Test and Functional MRI for the Presurgical Evaluation of Language in Epilepsy.Current neurology and neuroscience reports · 2017Pooled it
- Role of semantic paradigms for optimization of language mapping in clinical FMRI studies.AJNR. American journal of neuroradiology · 2013Trial
- Non-Invasive Mapping of the Neuronal Networks of Language.Brain sciences · 2023Review
- Use of longitudinal functional MRI to demonstrate translocation of language function in patients with brain tumors.Journal of neurosurgery · 2023Article
- A New Functional Magnetic Resonance Imaging Localizer for Preoperative Language Mapping Using a Sentence Completion Task: Validity, Choice of Baseline Condition, and Test-Retest Reliability.Frontiers in human neuroscience · 2022Article
- Feasibility, Contrast Sensitivity and Network Specificity of Language fMRI in Presurgical Evaluation for Epilepsy and Brain Tumor Surgery.Brain topography · 2021Article
- Article
- Neuroplasticity in post-stroke aphasia: A systematic review and meta-analysis of functional imaging studies of reorganization of language processing.Neurobiology of language (Cambridge, Mass.) · 2021Article
- Sex Effect on Presurgical Language Mapping in Patients With a Brain Tumor.Frontiers in neuroscience · 2020Article
- Functional MRI Task Comparison for Language Mapping in Neurosurgical Patients.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2019Article
- Characterization of brain network supporting episodic memory in the absence of one medial temporal lobe.Human brain mapping · 2019Article
- Article
- Repeatability of language fMRI lateralization and localization metrics in brain tumor patients.Human brain mapping · 2018Article
- Whole-Brain Network Connectivity Underlying the Human Speech Articulation as Emerged Integrating Direct Electric Stimulation, Resting State fMRI and Tractography.Frontiers in human neuroscience · 2018Article
- Limitations of Resting-State Functional MR Imaging in the Setting of Focal Brain Lesions.Neuroimaging clinics of North America · 2017Review
- Presurgical language fMRI: Mapping of six critical regions.Human brain mapping · 2017Article
- Language Mapping Using T2-Prepared BOLD Functional MRI in the Presence of Large Susceptibility Artifacts-Initial Results in Patients With Brain Tumor and Epilepsy.Tomography (Ann Arbor, Mich.) · 2017Article
- Improving language mapping in clinical fMRI through assessment of grammar.NeuroImage. Clinical · 2017Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionBlood oxygen level-dependent functional magnetic resonance imaging (fMRI) has demonstrated its capability to provide comparable results to gold standard intracarotid sodium amobarbital (Wada) testing for preoperative determination of language hemispheric dominance. However, thus far, no consensus has been established regarding which fMRI paradigms are the most effective for the determination of hemispheric language lateralization in specific categories of patients and specific regions of interest (ROIs).
methodsForty-one brain tumor patients who performed four different language tasks-rhyming (R), silent word generation (SWG) sentence completion, and sentence listening comprehension (LC)-for presurgical language mapping by fMRI were included in this study. A statistical threshold-independent lateralization index (LI) was calculated and compared among the paradigms in four different ROIs for language activation: functional Broca's (BA) and Wernicke's areas (WA) as well as larger anatomically defined expressive (EA) and receptive (RA) areas.
resultsThe two expressive paradigms evaluated in this study are very good lateralizing tasks in expressive language areas; specifically, a significantly higher mean LI value was noted for SWG (0.36 ± 0.25) compared to LC (0.16 ± 0.24, p = 0.009) and for R (0.40 ± 0.22) compared to LC (0.16 ± 0.24, p = 0.001) in BA. SWG LI (0.28 ± 0.19) was higher than LC LI (0.12 ± 0.16, p = 0.01) also in EA. No significant differences in LI were found among these paradigms in WA or RA.
conclusionsSWG and R are sufficient for the determination of lateralization in expressive language areas, whereas new semantic or receptive paradigms need to be designed for an improved assessment of lateralization in receptive language areas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.