ArticleJournal of peptide science : an official publication of the European Peptide Society2012
Peptaibols from two unidentified fungi of the order Hypocreales with cytotoxic, antibiotic, and anthelmintic activities.
Article in Journal of peptide science : an official publication of the European Peptide Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- A Journey into the Blue: Current Knowledge and Emerging Insights into Marine-Derived Peptaibols.Marine drugs · 2025Review
- Novel peptaibiotics identified from Trichoderma clade Viride.Natural products and bioprospecting · 2025Article
- Applications of tandem mass spectrometry (MS/MS) in antimicrobial peptides field: Current state and new applications.Heliyon · 2024Review
- Sheptide A: an antimalarial cyclic pentapeptide from a fungal strain in the Herpotrichiellaceae.The Journal of antibiotics · 2023Article
- The Potential ofNanomaterials (Basel, Switzerland) · 2023Review
- Peptaibols: Diversity, bioactivity, and biosynthesis.Engineering microbiology · 2022Review
- Rare Glutamic Acid Methyl Ester Peptaibols fromInternational journal of molecular sciences · 2021Article
- Three diketomorpholines from a Penicillium sp. (strain G1071).Phytochemistry · 2021Article
- The Emericellipsins A-E from an Alkalophilic FungusJournal of fungi (Basel, Switzerland) · 2021Article
- Sphaerostilbellins, New Antimicrobial Aminolipopeptide Peptaibiotics fromBiomolecules · 2020Article
- 14-Residue peptaibol velutibol A fromRSC advances · 2020Article
- Droplet probe: coupling chromatography to the in situ evaluation of the chemistry of nature.Natural product reports · 2019Review
- Metabolites from the Marine-FacultativeTetrahedron letters · 2019Article
- Development and Utilization of a Palladium-Catalyzed Dehydration of Primary Amides To Form Nitriles.Organic letters · 2018Article
- In situ mass spectrometry monitoring of fungal cultures led to the identification of four peptaibols with a rare threonine residue.Phytochemistry · 2017Article
- Unique amalgamation of primary and secondary structural elements transform peptaibols into potent bioactive cell-penetrating peptides.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Biosynthesis of Fluorinated Peptaibols Using a Site-Directed Building Block Incorporation Approach.Journal of natural products · 2017Article
- Prealamethicin F50 and related peptaibols fromRSC advances · 2017Article
- A new species of Trichoderma hypoxylon harbours abundant secondary metabolites.Scientific reports · 2016Article
- Discovery of Anticancer Agents of Diverse Natural Origin.Anticancer research · 2016Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
As part of an ongoing investigation of filamentous fungi for anticancer leads, an active culture was identified from the Mycosynthetix library (MSX 70741, of the order Hypocreales, Ascomycota). The fungal extract exhibited cytotoxic activity against the H460 (human nonsmall cell lung carcinoma) cell line, and bioactivity-directed fractionation yielded peptaibols 1-12 and harzianums A (13) and B (14). Structure elucidation of 1-12 was facilitated by high-resolution MS/MS using higher-energy collisional dissociation and by high field NMR (950 MHz). The absolute configuration was determined by Marfey's analysis of the individual amino acids; the time required for such analysis was decreased via the development of a 10-min ultra performance liquid chromatography method. The isolated peptaibols (1-12), along with three other peptaibols isolated and elucidated from a different fungus (MSX 57715) of the same order (15-17), were examined for activity in a suite of biological assays, including those for cytotoxic, antibacterial, and anthelmintic activities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.