Evidence map›Paper›PMID 22744705›Full record

ReviewCerebral cortex (New York, N.Y. : 1991)2013

'Til Eph do us part': intercellular signaling via Eph receptors and ephrin ligands guides cerebral cortical development from birth through maturation.

Hilary A North, Meredith A Clifford, Maria J Donoghue

Open access · bronzeAbstract readReview
In one paragraph

Review in Cerebral cortex (New York, N.Y. : 1991), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 29 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Canonical and Non-canonical Reelin Signaling.Frontiers in cellular neuroscience · 2016
    Review
  11. Article
  12. Review
  13. EphA7 signaling guides cortical dendritic development and spine maturation.Proceedings of the National Academy of Sciences of the United States of America · 2014
    Article
  14. Review
  15. The genetic basis of music ability.Frontiers in psychology · 2014
    Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Hilary A NorthDepartment of Biology and The Interdisciplinary Program in Neuroscience, Georgetown University, Washington, DC 20057, USA.
Meredith A Clifford
Maria J Donoghue
Georgetown University · US

Funding

EphA4 and ephrin-B1 signaling in cortical progenitor cell proliferationF31NS062550 · NINDS · GEORGETOWN UNIVERSITY · PI NORTH-SCHELER, HILARY · 2009 to 2010
$30k
NINDS NIH HHS F31NS062550
6 · The paper itself

Abstract

Eph receptors, the largest family of surface-bound receptor tyrosine kinases and their ligands, the ephrins, mediate a wide variety of cellular interactions in most organ systems throughout both development and maturity. In the forming cerebral cortex, Eph family members are broadly and dynamically expressed in particular sets of cortical cells at discrete times. Here, we review the known functions of Eph-mediated intercellular signaling in the generation of progenitors, the migration of maturing cells, the differentiation of neurons, the formation of functional connections, and the choice between life and death during corticogenesis. In synthesizing these results, we posit a signaling paradigm in which cortical cells maintain a life history of Eph-mediated intercellular interactions that guides subsequent cellular decision-making.

Indexed as

AnimalsCerebral CortexEphrinsNeural Stem CellsNeurogenesisReceptor, EphA1Signal TransductionEphrinsReceptor, EphA1cerebral cortexdevelopmentdifferentiationEph/ephrinparcellationproliferation

Identifiers

PMID22744705
PMCPMC3841399
OpenAlexW2159161449

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.