ArticleHernia : the journal of hernias and abdominal wall surgery2012
Inflammatory reaction and neotissue maturation in the early host tissue incorporation of polypropylene prostheses.
Article in Hernia : the journal of hernias and abdominal wall surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Trial
- Trial
- Recent Advances in Functional Hydrogel for Repair of Abdominal Wall Defects: A Review.Biomaterials research · 2024Article
- THE USE OF SURGICAL ADHESIVE AND SUTURE FIXING MESHES TO THE ABDOMINAL WALL: AN EXPERIMENTAL STUDY IN RATS.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2022Article
- BETWEEN PROLENE®, ULTRAPRO® AND BARD SOFT® MESHES WHICH PRESENTS THE BEST PERFORMANCE IN THE REPAIR OF THE ABDOMINAL WALL?Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2021Article
- Analysis of tissue inflammatory response, fibroplasia, and foreign body reaction between the polyglactin suture of abdominal aponeurosis in rats and the intraperitoneal implant of polypropylene, polypropylene/polyglecaprone and polyester/porcine collagen meshes.Acta cirurgica brasileira · 2021Article
- Could we reduce adhesions to the intra-abdominal mesh in the first week? Experimental study with different methods of fixation.Hernia : the journal of hernias and abdominal wall surgery · 2020Article
- Biocompatibility evaluation of heparin-conjugated poly(ε-caprolactone) scaffolds in a rat subcutaneous implantation model.Journal of materials science. Materials in medicine · 2020Article
- Experimental Investigation on the Tissue Response Induced by Face-Lifting Mesh Suspension Thread in Rats.Annals of dermatology · 2019Article
- Experimental study of inflammatory response and collagen morphometry with different types of meshes.Hernia : the journal of hernias and abdominal wall surgery · 2016Article
- Tissue integration and inflammatory reaction in full-thickness abdominal wall repair using an innovative composite mesh.Hernia : the journal of hernias and abdominal wall surgery · 2016Article
- Biomaterials for pelvic floor reconstructive surgery: how can we do better?BioMed research international · 2015Review
- Acute inflammatory response in the subcutaneous versus periprosthethic space after incisional hernia repair: an original article.BMC surgery · 2014Article
- Early and late postoperative inflammatory and collagen deposition responses in three different meshes: an experimental study in rats.Hernia : the journal of hernias and abdominal wall surgery · 2014Article
- Evaluation of three purely polypropylene meshes of different pore sizes in an onlay position in a New Zealand white rabbit model.Hernia : the journal of hernias and abdominal wall surgery · 2014Article
- Comparative study of shrinkage, inflammatory response and fibroplasia in heavyweight and lightweight meshes.Hernia : the journal of hernias and abdominal wall surgery · 2013Article
- TENSIOMETRIC ANALYSIS OF MESHES USED IN ABDOMINAL VENTRAL WALL DEFECTS IN RATS.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgeryArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe use prosthetic materials for the surgical repair of abdominal wall defects has become almost standard practice. This study was designed to assess the expression of different growth factors (VEGF/TGF-β1) and macrophages during the early host tissue incorporation of several polypropylene lightweight (PP-LW)-including one partially absorbable-and heavyweight (PP-HW) prosthetic meshes.
methodsVentral defects were created in the anterior abdominal wall of New Zealand rabbits and repaired by fixing PP-LW meshes of different pore size and a low porosity PP-HW mesh to the edges of the defect. Following killing 14 days after implant, specimens were taken to examine TGF-β1/VEGF gene and protein expression by qRT-PCR and immunohistochemistry. The macrophage response was also assessed.
resultsAll the materials showed good host tissue incorporation, with a more severe inflammatory reaction and greater numbers of macrophages recorded in the partially absorbable LW implants. Relative amounts of VEGF mRNA were significantly lower for the LW partially absorbable implants compared with the remaining LW meshes. Protein expression of VEGF showed undetectable or minimum staining in the different groups. TGF-β1 mRNA levels were also lower in the partially absorbable group compared with one of PP-LW type of mesh. Gene expression patterns were consistent with the TGF-β1 protein levels detected.
conclusionsThe results suggest that VEGF and TGF-β1 expression were independent of mesh pore size. The expression of both growth factors and the macrophage response were correlated with the presence of biodegradable material in the mesh. The presence of absorbable material in the LW mesh gave rise to a more intense inflammatory reaction and the reduced synthesis of growth factors known to contribute to neotissue maturation.
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