Trial reportEye (London, England)2012
Predictors of outcome in fungal keratitis.
Trial report in Eye (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- Medical interventions for fungal keratitis.The Cochrane database of systematic reviews · 2015Pooled it
- Predictors of Corneal Perforation or Need for Therapeutic Keratoplasty in Severe Fungal Keratitis: A Secondary Analysis of the Mycotic Ulcer Treatment Trial II.JAMA ophthalmology · 2017Trial
- Inhibition of TREM-1 and Dectin-1 Alleviates the Severity of Fungal Keratitis by Modulating Innate Immune Responses.PloS one · 2016Trial
- Successful Empirical Treatment of a Severe Corneal Abscess After Delayed Consultation in a Low-Resource Setting: A Case Report.Clinical case reports · 2026Article
- A Novel Mycovirus Reprograms the Pathogenic State of Aspergillus flavus in Keratitis.Investigative ophthalmology & visual science · 2026Article
- A thirteen-year tertiary centre experience with infectious keratitis in the elderly population.International ophthalmology · 2026Article
- Optimal infiltration depth threshold for low-temperature plasma ablation in fungal keratitis.Journal of ophthalmic inflammation and infection · 2025Article
- Comparison of Recurrent and Naïve Keratitis in a Cohort of 1303 Patients.Journal of clinical medicine · 2025Article
- Management of microbial keratitis by private pharmacies in Uganda: a study of knowledge, attitude, and practice.Wellcome open research · 2025Article
- Anatomic Biomarkers Predict Poor Presenting Visual Acuity in Infectious Keratitis.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Nanomedicine in fungal keratitis: current applications and future prospects.Frontiers in microbiology · 2025Review
- Clinical features, risk factors and outcomes of contact lens-related bacterial keratitis in Nottingham, UK: a 7-year study.Eye (London, England) · 2024Article
- Treatment Strategies for Filamentous Fungi Keratitis.Advances in therapy · 2024Article
- Monitoring the Progression of Clinically Suspected Microbial Keratitis Using Convolutional Neural Networks.Translational vision science & technology · 2023Article
- A positive feedback cycle between the alarmin S100A8/A9 and NLRP3 inflammasome-GSDMD signalling reinforces the innate immune response in Candida albicans keratitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023Article
- Clinical and mycological profile of fungal keratitis from North and North-East India.Indian journal of ophthalmology · 2022Article
- Epidemiology and clinical outcomes of microbial keratitis in South East Nepal: a mixed-methods study.BMJ open ophthalmology · 2022Article
- Clinical and Mycological Features of Fungal Keratitis: A Retrospective Single-Center Study (2012-2018)Turkish journal of ophthalmology · 2022Article
- Delay in accessing definitive care for patients with microbial keratitis in Nepal.Frontiers in medicine · 2022Article
- NLRP3 Inflammasome-Mediated Pyroptosis Pathway Contributes to the Pathogenesis ofFrontiers in medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo analyse predictors of clinical outcome in fungal keratitis.
methodsData was collected during a prospective, randomized, controlled, double-masked clinical trial of treatment for fungal keratitis. Clinical features at presentation and demographics were collected at the enrollment visit for all patients. Pre-specified clinical outcomes included 3-month visual acuity and infiltrate/scar size, time to re-epithelialization, and corneal perforation. A separate multivariable model with each outcome as the dependent variable included all predictor variables.
resultsPredictors for worse 3-month visual acuity include older age (P=0.024), worse presentation visual acuity (P<0.001), larger infiltrate size at presentation (P<0.001), and pigmented ulcer (P=0.030). Larger infiltrate size at presentation was a significant predictor of worse 3-month infiltrate/scar size (P<0.001). Larger epithelial defect size was a significant predictor of perforation (P=0.0013). Predictors of longer time to re-epithelialization include infiltrate size at presentation (P<0.001) and older age (P=0.025).
conclusionUlcer severity at presentation is highly predictive of worse outcomes. Presentation of clinical characteristics such as baseline acuity and infiltrate scar can provide important information to clinicians about prognosis, and may help guide management and treatment decisions. Prevention of corneal ulcer remains important, as it is difficult to change the course of the ulcer once it has begun.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.