ArticleLa Radiologia medica2013
Assessment of activity of Crohn's disease of the ileum and large bowel: proposal for a new multiparameter MR enterography score.
Article in La Radiologia medica, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Layered enhancement at magnetic resonance enterography in inflammatory bowel disease: A meta-analysis.World journal of gastroenterology · 2019Pooled it
- Assessment of Activity of Crohn Disease by Diffusion-Weighted Magnetic Resonance Imaging.Medicine · 2015Trial
- The usefulness of selected sequences of magnetic resonance imaging in a diagnostic model for Crohn's disease.Przeglad gastroenterologiczny · 2022Article
- Prevalence and clinical significance of incidental extra-intestinal findings in MR enterography: experience of a single University Centre.La Radiologia medica · 2021Article
- Magnetic resonance imaging and Crohn's disease endoscopic index of severity: Correlations and concordance.World journal of gastroenterology · 2018Article
- A review of magnetic resonance enterography-based indices for quantification of Crohn's disease inflammation.Therapeutic advances in gastroenterology · 2018Review
- Magnetic resonance enterography changes after antibody to tumor necrosis factor (anti-TNF) alpha therapy in Crohn's disease: correlation with SES-CD and clinical-biological markers.BMC medical imaging · 2016Article
- Assessment of Disease Activity in Small Bowel Crohn's Disease: Comparison between Endoscopy and Magnetic Resonance Enterography Using MRIA and Modified MRIA Score.Gastroenterology research and practice · 2015Article
- [Intestinal parasites simulating appendicitis on ultrasound: about two cases].The Pan African medical journal · 2015Article
- Accuracy of ultrasonography in the diagnosis of acute appendicitis in adult patients: review of the literature.Critical ultrasound journal · 2013Article
- The role of US examination in the management of acute abdomen.Critical ultrasound journal · 2013Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe evaluated the diagnostic accuracy of magnetic resonance enterography (MR-E) in assessing Crohn's disease (CD) activity by differentiating acute, chronic and remission stages of disease through a quantitative MR-E assessment. MATERIALS AND
methodsOne hundred patients with a histological diagnosis of CD were studied with MR-E. Intestinal distension was obtained by oral administration of approximately 2 L of a polyethylene glycol solution (PEG). In all cases, the ileum and large bowel were imaged with morphological sequences (heavily T2-weighted single-shot, dual fast-field echo, balanced fast-field echo) and a postcontrast dynamic sequence (T1-weighted high-resolution isotropic volume excitation). Disease activity was assessed according to a multiparameter score (0-8) based on lesion morphology, signal intensity and contrast enhancement. MR-E findings were compared with clinical-laboratory data and disease activity indices [Crohn's Disease Activity Index (CDAI); Inflammatory Bowel Disease Questionnaire (IBDQ)]. Multiple regression analysis was performed by correlating MR-E score, CDAI and IBDQ. Frequencies were then compared using the χ (2) test.
resultsMR-E identified inactive disease in 9% of cases, chronic disease in 57% and active disease in the remaining 34%. The most frequently involved bowel segment was the terminal ileum (52%). A statistically significant correlation was found between MR-E score and CDAI (R=0.86; p<0.001) and between MR-E score and IBDQ (R=-0.83; p<0.001). The most suggestive parameter for disease activity was layered bowel-wall enhancement, a finding predominantly present in patients with increased CDAI (≥ 150) and/or local complications (χ (2)=7.13; p<0.01).
conclusionsMR-E is a noninvasive and diagnostic imaging modality for CD study and follow-up. The MR-E score proposed in this study proved to be useful in assessing disease severity and monitoring response to treatment.
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