ArticleJournal of neurology2013
Acute seizures in acute ischemic stroke: does thrombolysis have a role to play?
Article in Journal of neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Incidence and risk factors of post-stroke seizures and epilepsy: systematic review and meta-analysis.The Journal of international medical research · 2023Pooled it
- The incidence and impact of early post-stroke seizures for successful endovascular stroke treatment: an individual patient data level analysis of trials.International journal of surgery (London, England) · 2026Article
- Decreased level of consciousness in acute ischemic stroke: risk factors, territories, stroke mechanisms and outcome. A single-centre cohort study.Journal of neurology · 2025Article
- Reperfusion Therapies and Post-Stroke Seizures: Evidence, Mechanisms and Clinical Implications-A Narrative Review.The Malaysian journal of medical sciences : MJMS · 2025Review
- Cortical Involvement of a Recent Infarct Contralateral to Early Focal Seizures in Ischemic Stroke.Internal medicine (Tokyo, Japan) · 2023Article
- Clinical Biomarkers and Prediction Models for Poststroke Epilepsy: Have We Settled the Scores Yet?Neurology. Clinical practice · 2023Article
- Epileptiform activity in the acute phase of stroke predicts the outcomes in patients without seizures.Frontiers in neurology · 2023Article
- Acute symptomatic seizures and status epilepticus in older adults: A narrative review focusing on management and outcomes.Frontiers in neurology · 2022Review
- Seizures and epilepsy in patients with ischaemic stroke.Neurological research and practice · 2021Review
- Early epileptic seizures in ischaemic stroke treated by mechanical thrombectomy: influence of rt-PA.Journal of neurology · 2021Article
- Effect of Reperfusion Therapies on Incidence of Early Post-Stroke Seizures.Frontiers in neurology · 2021Article
- Intravenous thrombolysis or mechanical thrombectomy do not increase risk of acute symptomatic seizures in patients with ischemic stroke.Scientific reports · 2020Article
- Chronic kidney disease in the pathogenesis of acute ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Review
- Incidence, Implications, and Management of Seizures Following Ischemic and Hemorrhagic Stroke.Current neurology and neuroscience reports · 2019Review
- Post-synaptic Release of the Neuronal Tissue-Type Plasminogen Activator (tPA).Frontiers in cellular neuroscience · 2019Article
- Risk Factors for Epilepsy After Thrombolysis for Ischemic Stroke: A Cohort Study.Frontiers in neurology · 2019Article
- Perfusion-CT imaging in epileptic seizures.Journal of neurology · 2018Article
- Antiepileptic drugs in critically ill patients.Critical care (London, England) · 2018Review
- Association between different acute stroke therapies and development of post stroke seizures.BMC neurology · 2018Article
- Frequency, determinants, and effects of early seizures after thrombolysis for acute ischemic stroke: The ENCHANTED trial.Neurology. Clinical practice · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Seizures appear at stroke presentation, during the acute phase or as a late complication of stroke. Thrombolysis has not been investigated as a risk factor despite its potential neurotoxic effect. We try to identify risk factors for seizures during the acute phase of ischemic stroke in a cohort including thrombolysed patients. We undertook a case-control study at a single stroke center using data from Acute Stroke Registry and Analyse of Lausanne (ASTRAL). Patients with seizure occurring during the first 7 days following stroke were retrospectively identified. Bi-variable and multivariable statistical analyses were applied to compare cases and randomly selected controls. We identified 28 patients experiencing from seizures in 2,327 acute ischemic strokes (1.2 %). All seizures occurred during the first 72 h. Cortical involvement, thrombolysis with rt-PA, arterial recanalization, and higher initial NIHSS were statistically associated with seizures in univariated analysis. Backward linear regression identified cortical involvement (OR 7.53, 95 % CI 1.6-35.2, p < 0.01) and thrombolysis (OR 4.6, 95 % CI 1.6-13.4, p = 0.01) as being independently associated with seizure occurrence. Overall, 3-month outcome measured by the modified Rankin scale (mRS) was comparable in both groups. In the subgroup of thrombolysed patients, outcome was significantly worse at 3 months in the seizure group with 9/12 (75 %) patients with mRS ≥ 3, compared to 6/18 (33.3 %) in the seizure-free group (p = 0.03). Acute seizures in acute ischemic stroke were relatively infrequent. Cortical involvement and thrombolysis with rt-PA are the principal risk factors. Seizures have a potential negative influence on clinical outcome in thrombolysed patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.