ArticleOptics letters2012
Multiple-gate time domain diffuse fluorescence tomography allows more sparse tissue sampling without compromising image quality.
Article in Optics letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 18 citations in OpenAlex.
- The Resolution Matrix in Tomographic Multiplexing: Optimization of Inter-Parameter Cross-Talk, Relative Quantitation, and Localization.IEEE transactions on bio-medical engineering · 2019Article
- Multiplexed fluorescence tomography with spectral and temporal data: demixing with intrinsic regularization.Biomedical optics express · 2016Article
- Macroscopic optical imaging technique for wide-field estimation of fluorescence depth in optically turbid media for application in brain tumor surgical guidance.Journal of biomedical optics · 2015Article
- Tomographic lifetime imaging using combined early- and late-arriving photons.Optics letters · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Diffuse fluorescence tomography systems that employ highly sensitive photo-multiplier tubes for single-photon detection are pushing the sensitivity limits of the field. However, each of these detectors only offers a single data projection to be collected, implying these imaging systems either require many detectors or long scan times to collect full data sets for image reconstruction. This study presents a method of utilizing the time-resolved collection capabilities of time-correlated single-photon counting techniques to increase spatial resolution and to reduce the number of data projections to produce reliable fluorescence reconstructions. Experimental tissue phantom results demonstrate that using data at 10 time gates in the fluorescence reconstructions for only 40 data projections provided superior image accuracy when compared to reconstructions on 320 continuous-wave data projections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.