ArticleInternational journal of oral science2012
Cementomimetics-constructing a cementum-like biomineralized microlayer via amelogenin-derived peptides.
Article in International journal of oral science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 61 citations in OpenAlex.
- Randomised in situ clinical trial investigating self-assembling peptide matrix P11-4 in the prevention of artificial caries lesions.Scientific reports · 2019Trial
- Embrace Disorder as a Function: Bio-Informed Biomaterials Design Advanced by Intrinsically Disordered Proteins.Biomimetics (Basel, Switzerland) · 2026Article
- Modulating silver diamine fluoride chemical derivatives by solid-binding peptides.Frontiers in bioengineering and biotechnology · 2026Article
- Cementum attachment protein-derived peptide induces cementum formation.FASEB bioAdvances · 2025Article
- In Vitro Investigation of Novel Peptide Hydrogels for Enamel Remineralization.Gels (Basel, Switzerland) · 2024Article
- Accurate informatic modeling of tooth enamel pellicle interactions by training substitution matrices with Mat4Pep.Frontiers in materials · 2024Article
- Dentinomimetics and cementomimetics of Moringa oleifera leaves extract.Scientific reports · 2023Article
- Biomimetic Dentin Repair: Amelogenin-Derived Peptide Guides Occlusion and Peritubular Mineralization of Human Teeth.ACS biomaterials science & engineering · 2023Article
- Peptides in Dentistry: A Scoping Review.Bioengineering (Basel, Switzerland) · 2023Article
- Amelogenin-Derived Peptide (ADP-5) Hydrogel for Periodontal Regeneration: An In Vitro Study on Periodontal Cells Cytocompatibility, Remineralization and Inflammatory Profile.Journal of functional biomaterials · 2023Article
- Amyloid-like amelogenin nanoribbons template mineralization via a low-energy interface of ion binding sites.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Peptide-Enabled Nanocomposites Offer Biomimetic Reconstruction of Silver Diamine Fluoride-Treated Dental Tissues.Polymers · 2022Article
- Engineering peptide-polymer hybrids for targeted repair and protection of cervical lesions.Frontiers in dental medicine · 2022Article
- Changes in the C-terminal, N-terminal, and histidine regions of amelogenin reveal the role of oligomer quaternary structure on adsorption and hydroxyapatite mineralization.Frontiers in physiology · 2022Article
- Advanced materials for enamel remineralization.Frontiers in bioengineering and biotechnology · 2022Review
- Minimal amelogenin domain for enamel formation.JOM (Warrendale, Pa. : 1989) · 2021Article
- Controls of nature: Secondary, tertiary, and quaternary structure of the enamel protein amelogenin in solution and on hydroxyapatite.Journal of structural biology · 2020Review
- Harnessing biomolecules for bioinspired dental biomaterials.Journal of materials chemistry. B · 2020Review
- In vitro remineralization of primary teeth with a mineralization-promoting peptide containing dental varnish.Journal of applied oral science : revista FOB · 2020Article
- Mitigation of peri-implantitis by rational design of bifunctional peptides with antimicrobial properties.ACS biomaterials science & engineering · 2020Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
Cementum is the outer-, mineralized-tissue covering the tooth root and an essential part of the system of periodontal tissue that anchors the tooth to the bone. Periodontal disease results from the destructive behavior of the host elicited by an infectious biofilm adhering to the tooth root and left untreated, may lead to tooth loss. We describe a novel protocol for identifying peptide sequences from native proteins with the potential to repair damaged dental tissues by controlling hydroxyapatite biomineralization. Using amelogenin as a case study and a bioinformatics scoring matrix, we identified regions within amelogenin that are shared with a set of hydroxyapatite-binding peptides (HABPs) previously selected by phage display. One 22-amino acid long peptide regions referred to as amelogenin-derived peptide 5 (ADP5) was shown to facilitate cell-free formation of a cementum-like hydroxyapatite mineral layer on demineralized human root dentin that, in turn, supported attachment of periodontal ligament cells in vitro. Our findings have several implications in peptide-assisted mineral formation that mimic biomineralization. By further elaborating the mechanism for protein control over the biomineral formed, we afford new insights into the evolution of protein-mineral interactions. By exploiting small peptide domains of native proteins, our understanding of structure-function relationships of biomineralizing proteins can be extended and these peptides can be utilized to engineer mineral formation. Finally, the cementomimetic layer formed by ADP5 has the potential clinical application to repair diseased root surfaces so as to promote the regeneration of periodontal tissues and thereby reduce the morbidity associated with tooth loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.