ArticleThe Journal of allergy and clinical immunology2012
Protection from asthma in a high-risk birth cohort by attenuated P2X(7) function.
Article in The Journal of allergy and clinical immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- P2X7 receptor: a potential therapeutic target for chronic respiratory diseases.Molecular and cellular biochemistry · 2026Review
- The P2X7 receptor in mucosal adaptive immunity.Purinergic signalling · 2024Review
- P2XAmerican journal of physiology. Lung cellular and molecular physiology · 2023Article
- Emerging Roles of Platelets in Allergic Asthma.Frontiers in immunology · 2022Review
- Eosinophils and Purinergic Signaling in Health and Disease.Frontiers in immunology · 2020Review
- Allergic sensitization increases the amount of extracellular ATP hydrolyzed by guinea pig leukocytes.Purinergic signalling · 2019Article
- Mast Cells and Their Progenitors in Allergic Asthma.Frontiers in immunology · 2019Review
- Human Invariant NKT Cells Induce IL-1β Secretion by Peripheral Blood Monocytes via a P2X7-Independent Pathway.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- P2X7 receptors induce degranulation in human mast cells.Purinergic signalling · 2016Article
- The Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases.Antioxidants & redox signaling · 2015Article
- Pathophysiological role of extracellular purinergic mediators in the control of intestinal inflammation.Mediators of inflammation · 2015Review
- Nucleotide signalling during inflammation.Nature · 2014Review
- Smoking enhances the proinflammatory effects of nucleotides on cytokine release from human lung.PloS one · 2014Article
- Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses.Purinergic signalling · 2013Review
- Virus/allergen interactions in asthma.Current allergy and asthma reports · 2013Review
- P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy.American journal of respiratory and critical care medicine · 2013Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundViral illnesses are important factors in both asthma inception and exacerbations, and allergic sensitization in early life further enhances asthma risk through unclear mechanisms. Cellular damage caused by infection or allergen inhalation increases ATP levels in the airways with subsequent purinergic receptor activation. The purinergic receptor P2X(7) can enhance airway leukocyte recruitment to the airways, and P2X(7) knockout mice display a reduced asthma-like phenotype.
objectiveBased on the P2X(7) knockout mouse, we hypothesized that children with low P2X(7) function would have decreased rates of asthma.
methodsWe used a functional assay to determine P2X(7) pore-producing capacity in whole-blood samples in a birth cohort at high risk for asthma development. The P2X(7) assay was validated with known loss-of-function alleles in human subjects. P2X(7) pore status categorization was used to assess asthma and allergy status in the cohort.
resultsAttenuated P2X(7) function was associated with lower asthma rates at ages 6 and 8 years, and the greatest effects were observed in boys. Children with asthma at age 11 years who had low P2X(7) capacity had less severe disease in the previous year. Attenuated P2X(7) function was also associated with sensitization to fewer aeroallergens.
conclusionP2X(7) functional capacity is associated with asthma risk or disease severity, and these relationships appear to be age related.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.