ArticleNeuroImage2012
Consistency and interpretation of changes in millimeter-scale cortical intrinsic curvature across three independent datasets in schizophrenia.
Article in NeuroImage, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Anomalous brain gyrification patterns in major psychiatric disorders: a systematic review and transdiagnostic integration.Translational psychiatry · 2021Pooled it
- Longitudinal Trajectories of Cortical Folding in Schizophrenia Spectrum Disorders: A 13-Year Follow-Up Study.Schizophrenia bulletin · 2026Article
- AN INTEGRATIVE NETWORK-BASED MEDIATION MODEL (NMM) TO ESTIMATE MULTIPLE GENETIC EFFECTS ON OUTCOMES MEDIATED BY FUNCTIONAL CONNECTIVITY.The annals of applied statistics · 2024Article
- Morphological Abnormalities in Early-Onset Schizophrenia Revealed by Structural Magnetic Resonance Imaging.Biology · 2023Article
- Edges in brain networks: Contributions to models of structure and function.Network neuroscience (Cambridge, Mass.) · 2022Review
- Grey and white matter microstructure is associated with polygenic risk for schizophrenia.Molecular psychiatry · 2021Article
- Examining volumetric gradients based on the frustum surface ratio in the brain in autism spectrum disorder.Human brain mapping · 2021Article
- Differential Patterns of Gyral and Sulcal Morphological Changes During Normal Aging Process.Frontiers in aging neuroscience · 2021Article
- Dissociations in cortical thickness and surface area in non-comorbid never-treated patients with social anxiety disorder.EBioMedicine · 2020Article
- Article
- BMI-related cortical morphometry changes are associated with altered white matter structure.International journal of obesity (2005) · 2019Article
- Healthy cortical development through adolescence and early adulthood.Brain structure & function · 2017Article
- Novel surface features for automated detection of focal cortical dysplasias in paediatric epilepsy.NeuroImage. Clinical · 2017Article
- No Association between Cortical Gyrification or Intrinsic Curvature and Attention-deficit/Hyperactivity Disorder in Adolescents and Young Adults.Frontiers in neuroscience · 2017Article
- Development of cortical shape in the human brain from 6 to 24months of age via a novel measure of shape complexity.NeuroImage · 2016Article
- Subject-level measurement of local cortical coupling.NeuroImage · 2016Article
- Multiple markers of cortical morphology reveal evidence of supragranular thinning in schizophrenia.Translational psychiatry · 2016Article
- Article
- Mean cortical curvature reflects cytoarchitecture restructuring in mild traumatic brain injury.NeuroImage. Clinical · 2016Article
- From genes to folds: a review of cortical gyrification theory.Brain structure & function · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Several studies have sought to test the neurodevelopmental hypothesis of schizophrenia through analysis of cortical gyrification. However, to date, results have been inconsistent. A possible reason for this is that gyrification measures at the centimeter scale may be insensitive to subtle morphological changes at smaller scales. The lack of consistency in such studies may impede further interpretation of cortical morphology as an aid to understanding the etiology of schizophrenia. In this study we developed a new approach, examining whether millimeter-scale measures of cortical curvature are sensitive to changes in fundamental geometric properties of the cortical surface in schizophrenia. We determined and compared millimeter-scale and centimeter-scale curvature in three separate case-control studies; specifically two adult groups and one adolescent group. The datasets were of different sizes, with different ages and gender-spreads. The results clearly show that millimeter-scale intrinsic curvature measures were more robust and consistent in identifying reduced gyrification in patients across all three datasets. To further interpret this finding we quantified the ratio of expansion in the upper and lower cortical layers. The results suggest that reduced gyrification in schizophrenia is driven by a reduction in the expansion of upper cortical layers. This may plausibly be related to a reduction in short-range connectivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.