ArticleAnalytical chemistry2012
Surface acoustic wave nebulization facilitating lipid mass spectrometric analysis.
Article in Analytical chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 56 citations in OpenAlex.
- Faster, better, and cheaper: harnessing microfluidics and mass spectrometry for biotechnology.RSC chemical biology · 2021Review
- Utilizing Surface Acoustic Wave Nebulization (SAWN) for the Rapid and Sensitive Ambient Ionization Mass Spectrometric Analysis of Organic Explosives.Journal of the American Society for Mass Spectrometry · 2019Article
- Applications of Acoustofluidics in Bioanalytical Chemistry.Analytical chemistry · 2019Article
- Rapid Food Product Analysis by Surface Acoustic Wave Nebulization Coupled Mass Spectrometry.Food analytical methods · 2018Article
- Surface Acoustic Wave Nebulisation Mass Spectrometry for the Fast and Highly Sensitive Characterisation of Synthetic Dyes in Textile Samples.Journal of the American Society for Mass Spectrometry · 2017Article
- Desorption in Mass Spectrometry.Mass spectrometry (Tokyo, Japan) · 2017Article
- Surface acoustic wave devices for chemical sensing and microfluidics: A review and perspective.Analytical methods : advancing methods and applications · 2017Article
- The emerging role of native mass spectrometry in characterizing the structure and dynamics of macromolecular complexes.Protein science : a publication of the Protein Society · 2015Review
- Interfacing low-energy SAW nebulization with Liquid Chromatography-Mass Spectrometry for the analysis of biological samples.Scientific reports · 2015Article
- Top-Down Strategies for the Structural Elucidation of Intact Gram-negative Bacterial Endotoxins.Chemical science · 2014Article
- 193 nm ultraviolet photodissociation mass spectrometry for the structural elucidation of lipid A compounds in complex mixtures.Analytical chemistry · 2014Article
- Surface acoustic wave microfluidics.Lab on a chip · 2013Review
- Efficient sample preparation in immuno-matrix-assisted laser desorption/ionization mass spectrometry using acoustic trapping.Biomicrofluidics · 2013Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Surface acoustic wave nebulization (SAWN) is a novel method to transfer nonvolatile analytes directly from the aqueous phase to the gas phase for mass spectrometric analysis. The lower ion energetics of SAWN and its planar nature make it appealing for analytically challenging lipid samples. This challenge is a result of their amphipathic nature, labile nature, and tendency to form aggregates, which readily precipitate clogging capillaries used for electrospray ionization (ESI). Here, we report the use of SAWN to characterize the complex glycolipid, lipid A, which serves as the membrane anchor component of lipopolysaccharide (LPS) and has a pronounced tendency to clog nano-ESI capillaries. We also show that unlike ESI SAWN is capable of ionizing labile phospholipids without fragmentation. Lastly, we compare the ease of use of SAWN to the more conventional infusion-based ESI methods and demonstrate the ability to generate higher order tandem mass spectral data of lipid A for automated structure assignment using our previously reported hierarchical tandem mass spectrometry (HiTMS) algorithm. The ease of generating SAWN-MS(n) data combined with HiTMS interpretation offers the potential for high throughput lipid A structure analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.