Evidence map›Paper›PMID 22742494›Full record

ArticleMolecular microbiology2012

Killing two birds with one stone: an ABC transporter regulates gene expression through sequestration of a transcriptional regulator at the membrane.

Boris Görke

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Molecular microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Boris GörkeDepartment of General Microbiology, Institute of Microbiology and Genetics, Georg-August-University, Grisebachstrasse 8, 37077 Göttingen, Germany. bgoerke@gwdg.de
University of Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcriptional regulators are controlled through various, mostly well-understood, principles. In the study of Richet et al., published in this issue of Molecular Microbiology, fluorescence microscopy was used to uncover an unorthodox mechanism that relies on the dynamic shuttling of a gene regulator between the membrane and the chromosome. When not occupied with transport, the maltose-specific ABC transporter sequesters and thereby inactivates its cognate transcriptional regulator MalT. Upon maltose transport, MalT is released from the membrane and activates the maltose utilization and transport genes. This mechanism prevents induction of MalT by endogenously produced maltotriose, which is the inducer. Thus, the maltose uptake system is a trigger transporter with a bi-functional role in transport and regulation.

Indexed as

Gene Expression Regulation, BacterialATP-Binding Cassette TransportersDNA-Binding ProteinsEscherichia coliEscherichia coli ProteinsTranscription FactorsATP-Binding Cassette TransportersDNA-Binding ProteinsEscherichia coli Proteinsmaltose transport system, E coliMalT protein, E coliTranscription Factors

Identifiers

PMID22742494
OpenAlexW2159608590

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.