ArticleTissue engineering. Part C, Methods2013
Characterization of dental epithelial stem cells from the mouse incisor with two-dimensional and three-dimensional platforms.
Article in Tissue engineering. Part C, Methods, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Spatial Regulation of Preameloblast Development in Response to Distal Mouse Incisor Injury.Calcified tissue international · 2026Article
- Lumican from DESC spheroids enhances odontoblastic differentiation of SCAPs.Stem cell research & therapy · 2025Article
- Fgf9 promotes incisor dental epithelial stem cell survival and enamel formation.Stem cell research & therapy · 2024Article
- Adult dental epithelial stem cell-derived organoids deposit hydroxylapatite biomineral.International journal of oral science · 2023Article
- Bioengineered Tooth Buds Exhibit Features of Natural Tooth Buds.Journal of dental research · 2018Article
- Maternal diabetes modulates offspring cell proliferation and apoptosis during odontogenesis via the TLR4/NF-κB signalling pathway.Cell proliferation · 2017Article
- Maternal diabetes modulates dental epithelial stem cells proliferation and self-renewal in offspring through apurinic/apyrimidinicendonuclease 1-mediated DNA methylation.Scientific reports · 2017Article
- Generation of Spheres from Dental Epithelial Stem Cells.Frontiers in physiology · 2017Article
- Odontogenic epithelial stem cells: hidden sources.Laboratory investigation; a journal of technical methods and pathology · 2015Review
- NFI-C2 temporal-spatial expression and cellular localization pattern during tooth formation.Development, growth & differentiation · 2015Article
- In vivo administration of dental epithelial stem cells at the apical end of the mouse incisor.Frontiers in physiology · 2015Article
- Topography design concept of a tissue engineering scaffold for controlling cell function and fate through actin cytoskeletal modulation.Tissue engineering. Part B, Reviews · 2014Review
- A pituitary homeobox 2 (Pitx2):microRNA-200a-3p:β-catenin pathway converts mesenchymal cells to amelogenin-expressing dental epithelial cells.The Journal of biological chemistry · 2014Article
- Tooth, hair and claw: comparing epithelial stem cell niches of ectodermal appendages.Experimental cell research · 2014Review
- Isolation and culture of dental epithelial stem cells from the adult mouse incisor.Journal of visualized experiments : JoVE · 2014Article
- On the cutting edge of organ renewal: Identification, regulation, and evolution of incisor stem cells.Genesis (New York, N.Y. : 2000) · 2014Review
- BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor.Nature cell biology · 2013Article
- The role of bioactive nanofibers in enamel regeneration mediated through integrin signals acting upon C/EBPα and c-Jun.Biomaterials · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Dental epithelial stem cells (DESCs) drive continuous growth in the adult mouse incisors. To date, a robust system for the primary culture of these cells has not been reported, and little is known about the basic molecular architecture of these cells or the minimal extracellular scaffolding that is necessary to maintain the epithelial stem cell population in an undifferentiated state. We report a method of isolating DESCs from the cervical loop of the mouse mandibular incisor. Cells were viable in a two-dimensional culture system and did not demonstrate preferential proliferation when grown on top of various substrates. Characterization of these cells indicated that E-cadherin, integrin alpha-6, and integrin beta-4 mark the DESCs both in vivo and in vitro. We also grew these cells in a three-dimensional microenvironment and obtained spheres with an epithelial morphology and expression patterns. Insights into the mechanisms of stem cell maintenance in vitro will help lay the groundwork for the successful generation of bioengineered teeth from adult DESCs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.