ArticleJournal of cardiothoracic surgery2012
May toxicity of amiodarone be prevented by antioxidants? A cell-culture study.
Article in Journal of cardiothoracic surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Effects of N-acetyl cysteine, vitamin E and vitamin C on liver glutathione levels following amiodarone treatment in rats.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2019Article
- The cytotoxic properties and apoptotic potential of N-butyl and 2-octyl cyanoacrylates used in surgical treatment of chronic venous insufficiency.Turk gogus kalp damar cerrahisi dergisi · 2019Article
- N-acetylcysteine treats intravenous amiodarone induced liver injury.World journal of gastroenterology · 2015Article
- Prevention of amiodarone-induced cardiac toxicity in male BALB/c mice by a nutrient mixture.Experimental and therapeutic medicine · 2014Article
- Effect of Aronia melanocarpa fruit juice on amiodarone-induced pneumotoxicity in rats.Pharmacognosy magazine · 2014Article
- Clinical observations of features in spectrum domain optical coherence tomography of amiodarone-induced retinopathy: Two case presentation.Taiwan journal of ophthalmologyArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAtrial Fibrillation is the most common arrhythmia encountered following cardiac surgery. The most commonly administered drug used in treatment and prophylaxis is amiodarone which has several toxic effects on major organ functions. There are few clinical data concerning prevention of toxic effects and there is no routinely suggested agent. The aim of this study is to document the cytotoxic effects of amiodarone on cell culture media and compare the cytoprotective effects of commonly used antioxidant agents.
methodsL929 mouse fibroblast cell line was cultured and 100,000 cells/well-plate were obtained. First group of cells were treated with increasing concentrations of amiodarone (20 to 180 μM) alone. Second and third group of cells were incubated with one-fold equimolar dose of vitamin C and N-acetyl cysteine prior to amiodarone exposure. The viability of cells were measured by MTT assay and the cytoprotective effect of each agent was compared.
resultsThe cytotoxicity of amiodarone was significant with concentrations of 100 μM and more. The viabilities of both vitamin C and N-acetyl cysteine treated cells were higher compared to untreated cells.
conclusionsVitamin C and N-acetyl cysteine are commonly used in the clinical setting for different purposes in context of their known antioxidant actions. Their role in prevention of amiodarone induced cytotoxicity is not fully documented. The study fully demonstrates the cytoprotective role of both agents in amiodarone induced cytotoxicity on cell culture media; more pronounced with vitamin C in some concentrations. The findings may be projectile for further clinical studies.
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