ArticleBrain and behavior2012
Does cerebral lateralization develop? A study using functional transcranial Doppler ultrasound assessing lateralization for language production and visuospatial memory.
Article in Brain and behavior, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 122 citations in OpenAlex.
- Cerebrovascular function and cognition in childhood: a systematic review of transcranial Doppler studies.BMC neurology · 2014Pooled it
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- Evidence for a Compensatory Relationship between Left- and Right-Lateralized Brain Networks.bioRxiv : the preprint server for biology · 2023Article
- Time course of right-hemisphere recruitment during word production following left-hemisphere damage: A single case of young stroke.The European journal of neuroscience · 2022Article
- Functional Connectivity of the Developing Mouse Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- The interactive functional biases of manual, language and attention systems.Cognitive research: principles and implications · 2022Article
- Plasticity of the language system in children and adults.Handbook of clinical neurology · 2022Review
- Lateralized effects of deep brain stimulation in Parkinson's disease: evidence and controversies.NPJ Parkinson's disease · 2021Review
- Finding hidden treasures: A child-friendly neural test of task-following in individuals using functional Transcranial Doppler ultrasound.Neuropsychologia · 2020Article
- Mirrored brain organization: Statistical anomaly or reversal of hemispheric functional segregation bias?Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Investigation into inconsistent lateralisation of language functions as a potential risk factor for language impairment.The European journal of neuroscience · 2020Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
In the majority of people, language production is lateralized to the left cerebral hemisphere and visuospatial skills to the right. However, questions remain as to when, how, and why humans arrive at this division of labor. In this study, we assessed cerebral lateralization for language production and for visuospatial memory using functional transcranial Doppler ultrasound in a group of 60 typically developing children between the ages of six and 16 years. The typical pattern of left-lateralized activation for language production and right-lateralized activation for visuospatial memory was found in the majority of the children (58%). No age-related change in direction or strength of lateralization was found for language production. In contrast, the strength of lateralization (independent of direction) for visuospatial memory function continued to increase with age. In addition, boys showed a trend for stronger right-hemisphere lateralization for visuospatial memory than girls, but there was no gender effect on language laterality. We tested whether having language and visuospatial functions in the same hemisphere was associated with poor cognitive performance and found no evidence for this "functional crowding" hypothesis. We did, however, find that children with left-lateralized language production had higher vocabulary and nonword reading age-adjusted standard scores than other children, regardless of the laterality of visuospatial memory. Thus, a link between language function and left-hemisphere lateralization exists, and cannot be explained in terms of maturational change.
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