Evidence map›Paper›PMID 22741069›Full record

ArticleBiomedical optics express2012

Endoscopic imaging of Cerenkov luminescence.

Sri-Rajasekhar Kothapalli, Hongguang Liu, Joseph C Liao, Zhen Cheng, Sanjiv Sam Gambhir

Abstract read
In one paragraph

Article in Biomedical optics express, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Cerenkov-specific contrast agents for detection of pH in vivo.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2015
    Article
  12. Article
  13. Cerenkov luminescence imaging of interscapular brown adipose tissue.Journal of visualized experiments : JoVE · 2014
    Article
  14. Article
  15. Review
  16. Cerenkov imaging.Advances in cancer research · 2014
    Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sri-Rajasekhar Kothapalli
Hongguang Liu
Joseph C Liao
Zhen Cheng
Sanjiv Sam Gambhir

Funding

Small Animal ImagingP50CA114747 · NCI · STANFORD UNIVERSITY · PI RAO, JIANGHONG · 2005 to 2014
$18.2M
Pilot ProjectsU54CA151459 · NCI · STANFORD UNIVERSITY · PI GAMBHIR, SANJIV S · 2010 to 2014
$12.6M
Optical Imaging of Bladder Cancer with Molecular Contrast AgentsR01CA160986 · NCI · STANFORD UNIVERSITY · PI LIAO, JOSEPH C · 2011 to 2014
$1.7M
VEGFR-2 Targeted ImagingR01CA128908 · NCI · STANFORD UNIVERSITY · PI CHENG, ZHEN · 2009 to 2011
$989k
NCI NIH HHS P50 CA114747NCI NIH HHS R01 CA128908NCI NIH HHS R01 CA160986NCI NIH HHS U54 CA151459
6 · The paper itself

Abstract

We demonstrate feasibility of endoscopic imaging of Cerenkov light originated when charged nuclear particles, emitted from radionuclides, travel through a biological tissue of living subjects at superluminal velocity. The endoscopy imaging system consists of conventional optical fiber bundle/ clinical endoscopes, an optical imaging lens system, and a sensitive low-noise charge coupled device (CCD) camera. Our systematic studies using phantom samples show that Cerenkov light from as low as 1 µCi of radioactivity emitted from (18)F-Fluorodeoxyglucose (FDG) can be coupled and transmitted through conventional optical fibers and endoscopes. In vivo imaging experiments with tumor bearing mice, intravenously administered with (18)F-FDG, further demonstrated that Cerenkov luminescence endoscopy is a promising new tool in the field of endoscopic molecular imaging.

Indexed as

(170.0110) Imaging systems(170.2150) Endoscopic imaging(170.4580) Optical diagnostics for medicine

Identifiers

PMID22741069
PMCPMC3370963

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.